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Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation
Open accessAbstract
Axo-dendritic synaptogenesis was examined in live hippocampal cell cultures using the fluorescent dyes DiO to label dendrites and FM 4-64 to label functional presynaptic boutons. As the first functional synaptic boutons appeared in these cultures, numerous filopodia (up to 10 micron long) were observed to extend transiently (mean lifetime 9.5 min) from dendritic shafts. With progressively increasing numbers of boutons, there were coincident decreases in numbers of transient filopodia and increases in numbers of stable dendritic spines. Dendritic filopodia were observed to initiate physical contacts with nearby axons. This sometimes resulted in filopodial stabilization and formation of functional presynaptic boutons. These findings suggest that dendritic filopodia may actively initiate synaptogenic contacts with nearby (5-10 micron) axons and thereafter evolve into dendritic spines.
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Cites
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862
Reconstruction of dendritic growth cones in neonatal mouse olfactory bulb
Hinds, J. W., & Hinds, P. L. (1972) · Journal of Neurocytology · doi:10.1007/bf01099183 · Cited by 113
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Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208
Rapid formation and selective stabilization of synapses for enduring motor memories
Xu, T., Yu, X., Perlik, A. J., Tobin, W. F., Zweig, J. A., Tennant, K., Jones, T., & Zuo, Y. (2009) · Nature · doi:10.1038/nature08389 · Cited by 1,193
Metadata
- Authors
- Ziv, N. E., & Smith, S. J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 17
- Issue
- 1
- Pages
- 91-102
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2106267269
- Cited by
- 862
- References
- 2
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ziv, N. E., & Smith, S. J. (1996). Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation. Neuron. https://doi.org/10.1016/s0896-6273(00)80283-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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