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Increased Exploratory Activity and Altered Response to LSD in Mice Lacking the 5-HT5A Receptor
Open accessAbstract
In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bulb, neocortex, and medial habenula. When exposed to novel environments, the 5A-KO mice displayed increased exploratory activity but no change in anxiety-related behaviors. In addition, the stimulatory effect of LSD on exploratory activity was attenuated in 5A-KO mice. These results suggest that 5-HT5A receptors modulate the activity of neural circuits involved specifically in exploratory behavior and suggest that some of the psychotropic effects of LSD may be mediated by 5-HT5A receptors.
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Cites
Wyman (1984) · doi:10.1007/978-1-4899-2286-1 · Cited by 413
Cited by
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297
An atlas of the protein-coding genes in the human, pig, and mouse brain
Sjöstedt, E., Zhong, W., Fagerberg, L., Karlsson, M., Mitsios, N., Adori, C., Oksvold, P., Edfors, F., Limiszewska, A., Hikmet, F., et al. (2020) · Science · doi:10.1126/science.aay5947 · Cited by 1,151
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 965
Nichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895
Metadata
- Authors
- Grailhe, R., Waeber, C., Dulawa, S. C., Hornung, J. P., Zhuang, X., Brunner, D., Geyer, M. A., & Hen, R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 22
- Issue
- 3
- Pages
- 581-591
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2071200330
- Cited by
- 202
- References
- 1
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Grailhe, R., Waeber, C., Dulawa, S. C., Hornung, J. P., Zhuang, X., Brunner, D., Geyer, M. A., & Hen, R. (1999). Increased Exploratory Activity and Altered Response to LSD in Mice Lacking the 5-HT5A Receptor. Neuron. https://doi.org/10.1016/s0896-6273(00)80712-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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