The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Open accessAbstract
Nonvoltage-gated cation currents, which are activated following stimulation of phospholipase C (PLC), appear to be major modes for Ca2+ and Na+ entry in mammalian cells. The TRPC channels may mediate some of these conductances since their expression in vitro leads to PLC-dependent cation influx. We found that the TRPC3 protein was highly enriched in neurons of the central nervous system (CNS). The temporal and spatial distribution of TRPC3 paralleled that of the neurotrophin receptor TrkB. Activation of TrkB by brain-derived nerve growth factor (BDNF) led to production of a PLC-dependent, nonselective cation conductance in pontine neurons. Evidence is provided that TRPC3 contributes to this current in vivo. Thus, activation of TrkB and PLC leads to a TRPC3-dependent cation influx in CNS neurons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [20]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [20]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Berridge, M. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80510-3 · Cited by 2,200
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T. W., & Schultz, G. (1999) · Nature · doi:10.1038/16711 · Cited by 1,511
Store depletion and calcium influx
Parekh, A. B., & Penner, R. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.901 · Cited by 1,398
Montell, C., & Rubin, G. M. (1989) · Neuron · doi:10.1016/0896-6273(89)90069-x · Cited by 1,151
Self-citationBerridge, M. J. (1995) · Biochemical Journal · doi:10.1042/bj3120001 · Cited by 1,095
Intracellular Signaling Pathways Activated by Neuropathic Factors
Segal, R. A., & Greenberg, M. E. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002335 · Cited by 955
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry
Merritt, J. E., Armstrong, W. P., Benham, C. D., Hallam, T. J., Jacob, R., Jaxa‐Chamiec, A. A., Leigh, B. K., McCarthy, S., Moores, K., & RINK, T. J. (1990) · Biochemical Journal · doi:10.1042/bj2710515 · Cited by 768
The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors
Hardie, R., & Minke, B. (1992) · Neuron · doi:10.1016/0896-6273(92)90086-s · Cited by 742
Cited by
Sorted by citations
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,996
Self-citation
Metadata
- Authors
- Li, H.-S., Xu, X.-Z. S., & Montell, C.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Montell, Craig
- ORCID
- Montell, Craig
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 24
- Issue
- 1
- Pages
- 261-273
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1968399538
- Cited by
- 345
- References
- 55
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 18
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY10852)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- TRPC3, TRPC channels, brain-derived neurotrophic factor, TrkB receptor, neurotrophin signaling, phospholipase C, calcium influx, sodium influx, pontine neurons, central nervous system neurons, cation conductance
- MeSH terms
- Animals, Cations, Cell Line, Cerebral Cortex, Electric Conductivity, Humans, Ion Channels, Neurons, Type C Phospholipases, Pons, Tissue Distribution, Transfection, Brain-Derived Neurotrophic Factor, Receptor, trkB, TRPC Cation Channels, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
