Regulation of Chemosensory Receptor Expression and Sensory Signaling by the KIN-29 Ser/Thr Kinase
Open accessAbstract
Sensory signals regulate multiple developmental and behavioral circuits in C. elegans, providing a genetically tractable system in which to investigate the mechanisms underlying the acquisition and integration of sensory information. kin-29 mutants are defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. kin-29 encodes a Ser/Thr kinase with similarity to the MARK and AMPK/SNF1 family of kinases. We show that KIN-29 acts cell-autonomously and non-cell-autonomously in sensory neurons to regulate chemoreceptor expression, body size, and the dauer decision, suggesting that kin-29 function is essential for the correct acquisition and transduction of sensory information.
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C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: gustatory plasticity, lifespan control, locomotion (roaming), and body size determination.
“Yet, C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: ability to sense and learn to avoid salt in the absence of food (gustatory plasticity); lifespan control; locomotion (roaming); and, body size determination40,42,47–51.”
From The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision (2022) · cites this paper as [50]
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References 102 · Cited by 71
- Authors
- Lanjuin, A., & Sengupta, P.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Sengupta, Piali
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 33
- Issue
- 3
- Pages
- 369-381
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2051577598
- Cited by
- 71
- References
- 102
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- David and Lucile Packard Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- Ser/Thr kinase, sensory signaling, Caenorhabditis elegans, body size regulation, lifespan, sensory neurons, MARK kinases
- MeSH terms
- Amino Acid Sequence, Animals, Chemoreceptor Cells, Cloning, Molecular, Gene Expression Regulation, Hot Temperature, Humans, Life Expectancy, Molecular Sequence Data, Mutation, Neurons, Afferent, Pheromones, Phylogeny, Recombinant Fusion Proteins, Signal Transduction, Helminth Proteins, Sequence Alignment, Caenorhabditis elegans, Protein Serine-Threonine Kinases, Genes, Reporter, Active Transport, Cell Nucleus, Caenorhabditis elegans Proteins, Animals, Genetically Modified
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