Polyribosomes Redistribute from Dendritic Shafts into Spines with Enlarged Synapses during LTP in Developing Rat Hippocampal Slices
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The presence of polyribosomes in dendritic spines suggests a potential involvement of local protein synthesis in the modification of synapses. Dendritic spine and synapse ultrastructure were compared after low-frequency control or tetanic stimulation in hippocampal slices from postnatal day (P)15 rats. The percentage of spines containing polyribosomes increased from 12% +/- 4% after control stimulation to 39% +/- 4% after tetanic stimulation, with a commensurate loss of polyribosomes from dendritic shafts at 2 hr posttetanus. Postsynaptic densities on spines containing polyribosomes were larger after tetanic stimulation. Local protein synthesis might therefore serve to stabilize stimulation-induced growth of the postsynaptic density. Furthermore, coincident polyribosomes and synapse enlargement might indicate spines that are expressing long-term potentiation induced by tetanic stimulation.
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BDNF action was selective on the spines that showed immediate enlargement, which may act as the structural tag for selective trapping of the protein-synthetic machinery and the capture of plasticity proteins for long-term spine-head enlargement.
“BDNF action was selective on the spines that showed immediate enlargement, which may act as the structural tag for selective trapping (26) of the protein-synthetic machinery (11, 27) and the capture of plasticity proteins (2, 28) for long-term spine-head enlargement.”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [27]
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References 68 · Cited by 461
- Authors
- Ostroff, L. E., Fiala, J. C., Allwardt, B., & Harris, K. M.
- Affiliations
- Boston University (US)
- Corresponding author
- Harris, Kristen M
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 35
- Issue
- 3
- Pages
- 535-545
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2143418370
- Cited by
- 461
- References
- 68
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 8 · 2023: 11 · 2022: 14 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 15 · 2017: 18 · 2016: 17 · 2015: 19 · 2014: 25 · 2013: 21 · 2012: 25
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4003 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH/DA57351, NS33574)
- National Institute of Mental Health
- National Institute of Development Administration
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- polysomes, dendritic spines, long-term potentiation, local protein synthesis, postsynaptic density, tetanic stimulation, hippocampus, dendritic shafts, synaptic ultrastructure, postnatal development
- MeSH terms
- Animals, Cell Compartmentation, Cell Differentiation, Dendrites, Electric Stimulation, Hippocampus, Male, Microscopy, Electron, Nerve Tissue Proteins, Synaptic Transmission, Organ Culture Techniques, Polyribosomes, RNA, Synapses, Presynaptic Terminals, Long-Term Potentiation, Rats, Long-Evans, Protein Transport, Cell Size, Rats
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