Regulation of Body Size and Behavioral State of C. elegans by Sensory Perception and the EGL-4 cGMP-Dependent Protein Kinase
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The growth and behavior of higher organisms depend on the accurate perception and integration of sensory stimuli by the nervous system. We show that defects in sensory perception in C. elegans result in abnormalities in the growth of the animal and in the expression of alternative behavioral states. Our analysis suggests that sensory neurons modulate neural or neuroendocrine functions, regulating both bodily growth and behavioral state. We identify genes likely to be required for these functions downstream of sensory inputs. Here, we characterize one of these genes as egl-4, which we show encodes a cGMP-dependent protein kinase. We demonstrate that this cGMP-dependent kinase functions in neurons of C. elegans to regulate multiple developmental and behavioral processes including the orchestrated growth of the animal and the expression of particular behavioral states.
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C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: gustatory plasticity, lifespan control, locomotion (roaming), and body size determination.
“Yet, C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: ability to sense and learn to avoid salt in the absence of food (gustatory plasticity); lifespan control; locomotion (roaming); and, body size determination40,42,47–51.”
From The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision (2022) · cites this paper as [48]
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References 45 · Cited by 344
- Authors
- Fujiwara, M., Sengupta, P., & McIntire, S. L.
- Affiliations
- University of California, San Francisco (US)
- Brandeis University (US)
- Corresponding author
- McIntire, Steven L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 36
- Issue
- 6
- Pages
- 1091-1102
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2070217895
- Cited by
- 344
- References
- 45
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 18 · 2023: 24 · 2022: 16 · 2021: 20 · 2020: 14 · 2019: 16 · 2018: 11 · 2017: 15 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 20 · 2012: 14
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns044232-10)
- National Institute of Neurological Disorders and Stroke (P01 NS-044232)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Caenorhabditis elegans, body size regulation, behavioral state, sensory perception, sensory neurons, egl-4, cGMP-dependent protein kinase, growth regulation, neuroendocrine signaling
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Behavior, Animal, Body Constitution, Chromosome Mapping, Cilia, Cloning, Molecular, Locomotion, Molecular Sequence Data, Mutation, Nervous System, Neurons, Afferent, Sensation, Helminth Proteins, Caenorhabditis elegans, Cyclic GMP-Dependent Protein Kinases, DNA, Complementary, Gene Expression Regulation, Developmental, Caenorhabditis elegans Proteins
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