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Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell
Open accessAbstract
The rules of synaptic integration in pyramidal cells remain obscure, in part due to conflicting interpretations of existing experimental data. To clarify issues, we developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings and combining results for two different response measures (peak versus mean EPSP), two different stimulus formats (single shock versus 50 Hz trains), and two different spatial integration conditions (within versus between-branch summation), we found that the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
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Cited by
London, M., & Häusser, M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135703 · Cited by 1,149
Computational subunits in thin dendrites of pyramidal cells
Polsky, A., Mel, B. W., & Schiller, J. (2004) · Nature Neuroscience · doi:10.1038/nn1253 · Cited by 817
Self-citationPyramidal Neuron as Two-Layer Neural Network
Poirazi, P., Brannon, T., & Mel, B. W. (2003) · Neuron · doi:10.1016/s0896-6273(03)00149-1 · Cited by 787
Self-citationCortical rewiring and information storage
Chklovskii, D. B., Mel, B. W., & Svoboda, K. (2004) · Nature · doi:10.1038/nature03012 · Cited by 717
Self-citationIntegrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons
Losonczy, A., & Magee, J. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.016 · Cited by 649
Metadata
- Authors
- Poirazi, P., Brannon, T., & Mel, B. W.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 37
- Issue
- 6
- Pages
- 977-987
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2000509838
- Cited by
- 438
- References
- 0
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Poirazi, P., Brannon, T., & Mel, B. W. (2003). Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell. Neuron. https://doi.org/10.1016/s0896-6273(03)00148-x
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
