Coupling of Total Hemoglobin Concentration, Oxygenation, and Neural Activity in Rat Somatosensory Cortex
Open accessAbstract
Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report represents the first systematic study with sufficient statistical power to quantitatively characterize the relationship between changes in blood oxygen content and the neural spiking and synaptic activity. Using two-dimensional optical measurements of hemodynamic signals, simultaneous recordings of neural activity, and an event-related stimulus paradigm, we demonstrate that (1) there is a strongly nonlinear relationship between electrophysiological measures of neuronal activity and the hemodynamic response, (2) the hemodynamic response continues to grow beyond the saturation of electrical activity, and (3) the initial increase in deoxyhemoglobin that precedes an increase in blood volume is counterbalanced by an equal initial decrease in oxyhemoglobin.
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After forelimb stimulation, the reflected light signal within the forelimb area was reduced, consistent with a local increase in deoxyhemoglobin associated with increased neuronal activity.
“After forelimb stimulation (over 1.5 s), the reflected light signal within the forelimb area was reduced consistent with a local increase in deoxyhemoglobin associated with increased neuronal activity (supplemental Fig. 1, available at www.jneurosci.org as supplemental material) (Devor et al., 2003;Dunn et al., 2005).”
From Two-Photon Imaging of Stroke Onset<i>In Vivo</i>Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines (2008) · cites this paper as Devor et al., 2003
The Results report a localized optical response after whisker stimulation and an initial increase in deoxyhemoglobin. The source studied rat whisker (barrel) cortex, not forelimb stimulation or the forelimb area, so it does not support those specifics or the stated 1.5-second stimulation period. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe cascade of metabolic and vascular events known as neurovascular coupling involves complex signaling among neurons, astrocytes, and the local vasculature and remains a topic of active research.
“Such a cascade of metabolic and vascular events, known as the neurovascular coupling, involves complex signaling among neurons, astrocytes, and the local vasculature (124, 126, 127), and remains a topic of active research enabled by emerging tools (128).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [127]
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References 55 · Cited by 387
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Research works printed but not linked: 5
- [6]6. Brinker, G. ∙ Bock, C. ∙ Busch, E. ... Simultaneous recording of evoked potentials and T2*-weighted MR images during somatosensory stimulation of rat Magn. Reson. Med. 1999; 41:469-473 Crossref Scopus (114) PubMed Google Scholar
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- Authors
- Devor, A., Dunn, A. K., Andermann, M. L., Ulbert, I., Boas, D. A., & Dale, A. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Devor, Anna
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 39
- Issue
- 2
- Pages
- 353-359
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2142205905
- Cited by
- 387
- References
- 55
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 14 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 17 · 2017: 11 · 2016: 16 · 2015: 11 · 2014: 14 · 2013: 18 · 2012: 21
- FWCI
- 17.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS044623)
- National Institute of Biomedical Imaging and Bioengineering (R01EB00790-01A2, R01EB000790)
- National Center for Research Resources (P41-RR-14075, R01RR013609, R01-RR13609, P41RR014075)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- hemodynamic response, neuronal activity, somatosensory cortex, blood oxygenation, deoxyhemoglobin, oxyhemoglobin, blood volume, neural spiking, functional MRI, nonlinear relationship, rats
- MeSH terms
- Animals, Brain Mapping, Computer Simulation, Demography, Electric Stimulation, Electrophysiology, Evoked Potentials, Somatosensory, Hemodynamics, Hemoglobins, Magnetic Resonance Imaging, Neurons, Oxygen, Somatosensory Cortex, Spectrum Analysis, Time Factors, Nonlinear Dynamics, Rats
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