The development of the paired fins in the zebrafish (Danio rerio).
Open accessAbstract
In the present study, we describe the structure and normal development of the zebrafish (Danio rerio) paired fins. Particularly, we focus on the structure of the apical epidermis and on endoskeletal morphogenesis. Endoskeletal development proceeds differently in the pectoral and pelvic fins. Whereas in both fins major parts of the endoskeletal girdle develop within the fin bud mesenchyme, the pattern of chondrogenic condensations observed in the pelvic fins directly reflects the adult endoskeletal pattern. In the pectoral fin, a morphogenetic detour is taken via a functional larval endoskeleton, the endoskeletal disc. It arises in the fin bud mesenchyme from a chondrogenic anlage common with the girdle. The disc chondrifies and represents the functional endoskeleton of the larval pectoral fin. The pectoral fin endoskeleton is expanded as well as restructured during larval stages in a process which involves decomposition of cartilage matrix in the endoskeletal disc. Our comparisons of apical fold morphology with reports on other teleosts and tetrapod apical ridges show them to be homologous on the structural level. Comparisons of endoskeletal development of the zebrafish with reports on teleosts, actinopterygians and chondrichthyans show that endoskeletal morphogenesis in the zebrafish pectoral fin follows a morphogenetic process which is wide-spread among actinopterygians.
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In zebrafish, the AER is involved in larval patterning of the paired fins, while later stages of fin development are organized by an analogous epidermal formation of the fin fold in both paired and unpaired fins.
“In zebrafish, the AER is involved in larval patterning of the paired fins, while the later stages of fin development are organized by an analogous epidermal formation of the fin fold in both paired and unpaired fins [26],[27].”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [26]
The comparative-analysis section describes the paired-fin apical folds as structurally homologous to tetrapod AERs and says they form much like the embryonic median fin fold. But the Introduction says the organizing centers’ function in zebrafish had not been demonstrated, and the Conclusions say tests of apical-fold function were still under way. The paper therefore does not establish that the AER patterns larval paired fins or that the fin fold organizes later development in both paired and unpaired fins. Page numbers were not available in our copy. (LLM, conf=0.88)
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- Authors
- Grandel, H., & Schulte-Merker, S.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 79
- Issue
- 1-2
- Pages
- 99-120
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2062632483
- Cited by
- 267
- References
- 0
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 6 · 2012: 11
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Fish Biology and Ecology Studies
- Keywords
- paired fins, zebrafish, pectoral fin, pelvic fin, fin development, Actinopterygii, teleost evolution
- MeSH terms
- Animals, Cell Differentiation, Ectoderm, Embryo, Nonmammalian, Endoderm, Extremities, Larva, Skeleton, Zebrafish
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