The DOI matches its Crossref record; 14 of the 16 references it cites were found in a registry or an index.
Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
Open accessAbstract
Whole mount in situ hybridisation was used to study the embryonic expression of the mouse HMG box-containing genes Sox1, Sox2 and Sox3 between 6.5 and 9.0 days post coitum (dpc). Sox2 and Sox3 are expressed in the epiblast and extraembryonic ectoderm of the egg cylinder, becoming restricted to the prospective neural plate and chorion at the onset of gastrulation. Sox3 is upregulated in the posterior ectoderm during late streak and neural plate stages and is concomitantly downregulated in the chorion. Sox1 transcripts are first detected in the neural fold ectoderm at the headfold stage. During early somitogenesis, all three genes are expressed in the neuroectoderm, and Sox2 and Sox3 are also expressed in the primitive streak ectoderm, gut endoderm and prospective sensory placodes.
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“Similarly, Sox2 is expressed in both ectoderm and endoderm libraries corresponding to published expression patterns [38].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [38]
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Cites
In situ hybridization; a practical approach
(1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90093-t · Cited by 1,240
Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope
Downs, K. M., & Davies, T. J. (1993) · Development · doi:10.1242/dev.118.4.1255 · Cited by 582
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
Collignon, J., Sockanathan, S., Hacker, A., Cohen‐Tannoudji, M., Norris, D. P., Rastan, S., Stevanović, M. J., Goodfellow, P. N., & Lovell-Badge, R. H. (1996) · Development · doi:10.1242/dev.122.2.509 · Cited by 496
Pevny, L., & Lovell-Badge, R. H. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80147-5 · Cited by 489
A role for SOX1 in neural determination
Pevny, L., Sockanathan, S., Placzek, M., & Lovell-Badge, R. H. (1998) · Development · doi:10.1242/dev.125.10.1967 · Cited by 475
Uwanogho, D., Rex, M., Cartwright, E. J., Pearl, G., Healy, C., Scotting, P. J., & Sharpe, P. T. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00299-3 · Cited by 391
Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in micePreprint
Nishiguchi, S., Wood, H. B., Kondoh, H., Lovell-Badge, R. H., & Episkopou, V. (1998) · Genes & Development · doi:10.1101/gad.12.6.776 · Cited by 290
Self-citationClonal Analysis of Cell Fate During Gastrulation and Early Neurulation in the Mouse
Lawson, K. A., & Pedersen, R. A. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514221.ch2 · Cited by 177
Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2
Streit, A., Sockanathan, S., Pérez, L., Rex, M., Scotting, P. J., Sharpe, P. T., Lovell-Badge, R. H., & Stern, C. D. (1997) · Development · doi:10.1242/dev.124.6.1191 · Cited by 159
Establishment and Organization of Germ Layers in the Gastrulating Mouse Embryo
Tam, P., & Beddington, R. S. P. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514221.ch3 · Cited by 152
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Sorted by citations
Multipotent cell lineages in early mouse development depend on SOX2 functionPreprint
Avilion, A. A., Nicolis, S. K., Pevny, L., Pérez, L., Vivian, N., & Lovell-Badge, R. H. (2003) · Genes & Development · doi:10.1101/gad.224503 · Cited by 2,372
“1B) and later in the ExE portion of the chorion (Fig. 1C–E; Wood and Episkopou 1999).”
BackgroundInfluentialDirected differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504
“Sox1 is the earliest known specific marker of neuroectoderm in the mouse embry”
BackgroundSOX2 Functions to Maintain Neural Progenitor Identity
Graham, V., Khudyakov, J. I., Ellis, P., & Pevny, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00497-5 · Cited by 1,344
“To address the role of SOX2 in CNS progenitors, we al., 1999; Pevny et al., 1998; Uchikawa et al., 2003; Uwaperformed a detailed study of SOX2 protein expression nogho et al., 1995; Wood and Episkopou, 1999 ).”
The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate
Sarkar, A., & Hochedlinger, K. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.007 · Cited by 915
Metadata
- Authors
- Wood, H. B., & Episkopou, V.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Episkopou, Vasso
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 86
- Issue
- 1-2
- Pages
- 197-201
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2055664397
- Cited by
- 550
- References
- 16
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 5 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 23 · 2016: 14 · 2015: 31 · 2014: 29 · 2013: 24 · 2012: 30
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- SOX1, SOX2, SOX3, gene expression, mouse embryo, gastrulation, neural plate, neural fold, somitogenesis, primitive streak, chorion, extraembryonic ectoderm, neuroectoderm
- MeSH terms
- Animals, Central Nervous System, DNA-Binding Proteins, Ectoderm, Embryo, Mammalian, Gastrula, High Mobility Group Proteins, Nuclear Proteins, Rhombencephalon, Transcription Factors, Gene Expression Regulation, Developmental, HMGB Proteins, Mice, SOXB1 Transcription Factors
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