Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis
Open accessAbstract
Activity-regulated, cytoskeleton-associated protein (Arc) was first identified as an immediate-early gene regulated by synaptic activity. We have studied its functional role in vivo using a gene-targeting approach. We found that Arc is encoded by a single exon, and Arc mRNA is ubiquitously expressed in early mouse embryos. Homozygous Arc mutants are severely growth-retarded, fail to gastrulate and subsequently die before day 8.5 of embryogenesis. Further analysis revealed severe disorganization of visceral endoderm formation, and total separation and ectopic location of embryonic and extraembryonic structure. These findings demonstrate that Arc function is essential for early embryo development and patterning in mice, and support the hypothesis that signaling from visceral endoderm is essential for normal patterning of the extraembryonic and embryonic structure.
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Throughout early mouse development, CYFIP1 signalling events, probably via its core conserved actin-regulatory functions, are likely critical for gastrulation and normal patterning of embryonic structure.
“Therefore, throughout early mouse development, CYFIP1 signalling events, probably via its core conserved actin-regulatory functions, are likely critical for gastrulation and normal patterning of embryonic structure in addition to later roles in neuronal development and plasticity.72”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [72]
Section 3.2 discusses defects in Arc-null mouse embryos, early patterning, and a possible relationship between Arc and the actin cytoskeleton. The Introduction likewise concerns Arc’s neuronal functions. A search for CYFIP1 found no passage addressing CYFIP1 signalling or its proposed role in gastrulation, so this copy cannot verify the claim attributed to it. (LLM, conf=0.78)
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Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., & Zaret, K. S. (1993) · Development · doi:10.1242/dev.119.4.1301 · Cited by 618 · see citing works
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Research works printed but not linked: 4
- Hogan, B., Beddington, R., Costantini, F., Lacy, E., 1994. Manipulating the Mouse Embryo: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
- Link, W., Konietzko, U., Kauselmann, G., Krug, M., Schwanke, B., Frey, U., Kuhl, D., 1995. Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Proc. Natl. Acad. Sci. USA 92, 5734±5738.
- Varlet, I., Collignon, J., Norris, D.P., Robertson, E.J., 1998. Symposia of Quantitative Biology, vol. LXII, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 105±113.
- Wilkinson, D.G., 1992. Whole-mount in situ hybridization of vertebrate embryos. In: Wilkinson, D.G. (Ed.). In Situ Hybridization: A Practical Approach, IRL Press, Oxford, pp. 75±83.
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Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827 · see citing works
Pathania, M., Davenport, E. C., Muir, J., Sheehan, D. F., López-Doménech, G., & Kittler, J. T. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.16 · Cited by 189 · see citing works
- Authors
- Liu, D., Bei, D., Parmar, H., & Matus, A.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Matus, Andrew
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 92
- Issue
- 2
- Pages
- 207-215
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2094386980
- Cited by
- 24
- References
- 1
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2017: 2 · 2016: 2 · 2014: 2 · 2012: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
- Keywords
- Arc, activity-regulated cytoskeleton-associated protein, visceral endoderm, gastrulation, early embryonic development, embryonic patterning, gene targeting, mouse embryo, growth retardation
- MeSH terms
- Animals, Cytoskeletal Proteins, Endoderm, Exons, Genes, Lethal, Mesoderm, Mice, Inbred C57BL, Mice, Inbred Strains, Nerve Tissue Proteins, Recombination, Genetic, Viscera, Mice, Knockout, Gene Expression Regulation, Developmental, Body Patterning, Mice
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