Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder
Abstract
Borderline personality disorder (BPD) is a common disorder associated with emotional dysregulation and other symptoms that have been hypothesized to be related to dysfunction of limbic brain areas including hippocampus and amygdala. The purpose of this study was to measure hippocampal and amygdala volumes in BPD. Hippocampal and amygdala volumes were measured with magnetic resonance imaging (MRI) in 10 patients with BPD and 23 control subjects. Patients with BPD had a 21.9% smaller mean amygdala volume and a 13.1% smaller hippocampal volume, compared to controls. These findings are consistent with the hypothesis that alterations in the hippocampus and amygdala are associated with BPD.
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Magnetic resonance imaging has revealed reductions in amygdala volumes among women who were sexually abused as children.
“Magnetic resonance imaging (MRI) has revealed reductions in hippocampus (Bremner 1997, 2003a; Stein 1997), and amygdala (Driessen 2000; Schmahl 2003) volumes as well as deficits in verbal declarative memory measured with neuropsychological testing (Teicher 2000; Heim and Nemeroff 2001) among women who were sexually abused as children.”
From The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology (2006) · cites this paper as Schmahl 2003
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References 25 · Cited by 319
- Authors
- Schmahl, C. G., Vermetten, E., Elzinga, B. M., & Douglas Bremner, J.
- Affiliations
- University of Freiburg (DE)
- University Medical Center Utrecht (NL)
- Leiden University (NL)
- Corresponding author
- Schmahl, Christian G.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 122
- Issue
- 3
- Pages
- 193-198
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2107983778
- Cited by
- 319
- References
- 25
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 15 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 23 · 2013: 21 · 2012: 23
- FWCI
- 17.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- borderline personality disorder, childhood abuse, hippocampal volume, amygdala volume, limbic system dysfunction, emotional dysregulation, brain structural changes
- MeSH terms
- Adult, Amygdala, Analysis of Variance, Borderline Personality Disorder, Child, Child Abuse, Female, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging
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