The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients
Open accessAbstract
Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections and the mutations in the TLR2 have been shown to confer the susceptibility to severe infection with mycobacteria. To define this, we screened the intracellular domain of TLR2 in 131 subjects. Groups of 45 lepromatous and 41 tuberculoid leprosy (TT) patients and 45 controls were investigated. Ten subjects among the lepromatous leprosy (LL) patients had a band variant detected by single-stranded conformational polymorphism. DNA sequencing detected a C to T substitution at nucleotide 2029 from the start codon of the TLR2. The mutation would substitute Arg to Trp at amino acid residue 677, one of the conserved regions of TLR2. In our results, the mutation was involved in only LL, not TT and control. Thus, we suggest that the mutation in the intracellular domain of TLR2 has a role in susceptibility to LL.
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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
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Cited by
Toll-like receptors in the pathogenesis of human disease
Cook, D. N., Pisetsky, D. S., & Schwartz, D. A. (2004) · Nature Immunology · doi:10.1038/ni1116 · Cited by 832
Britton, W. J., & Lockwood, D. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15952-7 · Cited by 687
Bafica, A., Scanga, C. A., Feng, C. G., Leifer, C., Cheever, A., & Sher, A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051782 · Cited by 601
Toll-like receptors induce a phagocytic gene program through p38
Doyle, S. E., O'Connell, R. M., Miranda, G. A., Vaidya, S. A., Chow, E. K., Liu, P. T., Suzuki, S., Suzuki, N., Modlin, R. L., Yeh, W.-C., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031237 · Cited by 433
Melmed, G., Thomas, L. S., Lee, N., Tesfay, S. Y., Lukasek, K., Michelsen, K. S., Zhou, Y., Hu, B., Arditi, M., & Abreu, M. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1406 · Cited by 431
Metadata
- Authors
- Kang, T.
- Venue
- FEMS Immunology and Medical Microbiology
- Publisher
- Wiley
- Published
- 2001-07
- Volume
- 31
- Issue
- 1
- Pages
- 53-58
- ISSN
- 0928-8244 (ISSN-L)
- OpenAlex
- W1996573346
- Cited by
- 269
- References
- 23
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kang, T. (2001). Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunology and Medical Microbiology. https://doi.org/10.1016/s0928-8244(01)00239-5
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