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Role of the bactericidal/permeability-increasing protein in host defence
Open accessAbstract
Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally distinct domains: a potently antibacterial and anti-endotoxin amino-terminal domain (approximately 20 kDa) and a carboxy-terminal portion that imparts opsonic activity to BPI. A recombinant amino-terminal fragment (rBPI21) protects animals against the effects of Gram-negative bacteria and endotoxin. In man, rBPI21 is nontoxic and non-immunogenic and is in Phase II/III clinical trials with apparent therapeutic benefit.
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Cited by
Levin, M., Quint, P. A., Goldstein, B., Barton, P., Bradley, J. S., Shemie, S., Yeh, T., Kim, S. S., Cafaro, D. P., Scannon, P. J., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02712-4 · Cited by 411
Canny, G., Levy, O., Furuta, G. T., Narravula-Alipati, S., Sisson, R. B., Serhan, C. N., & Colgan, S. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052533799 · Cited by 295
Metadata
- Authors
- Elsbach, P., & Weiss, J.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 10
- Issue
- 1
- Pages
- 45-49
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2064768582
- Cited by
- 214
- References
- 0
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Role of the bactericidal/permeability-increasing protein in host defence. https://app.cochat.ai/papers/10.1016/s0952-7915(98)80030-7
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- Elsbach, P., & Weiss, J. (1998). Role of the bactericidal/permeability-increasing protein in host defence. Current Opinion in Immunology. https://doi.org/10.1016/s0952-7915(98)80030-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
