Hyperventilation during exercise: independence on exercise-induced bronchoconstriction in mild asthma
Open accessAbstract
Ventilatory gas exchange during exercise was compared in patients with mild asthma (11 females and 11 males), hyperventilation syndrome (HVS, 11 females), and healthy subjects (11 females and 11 males) in order to assess hyperventilation during exercise and its association with exercise-induced bronchoconstriction. The asthmatics showed decreased working capacity and decreased maximal oxygen consumption, with no evidence of limitation due to impairment of ventilatory capacity. Ventilatory equivalents for CO2 and O2 (VE/VCO2 and VE/VO2) at rest did not differ between the controls and asthmatics, but they were significantly elevated in HVS. In female asthmatics, ventilatory equivalents during exercise were significantly (P < 0.05) elevated compared with those of healthy subjects; in female controls, VE/VCO2 was 30.1 +/- 3.3 at low exercise and 27.4 +/- 6.5 at maximal exercise. In female asthmatics, the corresponding figures were 34.9 +/- 6.1 and 36.7 +/- 5.3. Furthermore, VE/VCO2 individually related to percent of maximal oxygen consumption (VO2max) was significantly increased in female asthmatics both at low and high VO2. The highest ventilatory equivalents were obtained in HVS, 41.7 +/- 6.7 and 43.9 +/- 0.9, respectively. Significant exercise-induced bronchoconstriction (decrease of FEV1 > 15%) was found in 50% of the asthmatics. The ventilatory equivalents did not correlate with exercise-induced changes in FEV1 (r2 < 0.3). Mild exercise-induced hyperventilation which was observed in mild female asthmatics, did not appear to be related to exercise-induced bronchoconstriction.
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Exercise-induced hyperventilation occurs in a subgroup of patients who develop chest discomfort and dyspnoea during cardiopulmonary exercise testing independent of bronchospasm and unresponsive to beta agonist therapy, distinguishing it from exercise-induced asthma.
“Exercise-induced hyperventilation occurs in a subgroup of patients who develop chest discomfort and dyspnoea during cardiopulmonary exercise testing independent of bronchospasm and unresponsive to beta agonist therapy, thus distinguishing it from exercise-induced asthma [58, 59].”
From Dysfunctional breathing: a review of the literature and proposal for classification (2016) · cites this paper as [59]
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Research works printed but not linked: 4
- Spiro SG, Dowdeswell IRG, Clark TJH. An analysis of submaximal exercise responses in patients with sar- coidosis and fibrosing alveolitis. Br J Dis Chest 1981; 75: 169-180.
- Burdon JGW, Killian KJ, Jones NL. Pattern of breath- ing during exercise in patients with interstitial lung disease. Thorax 1983; 38: 778-784.
- Javaheri S, Sicilian L. Lung function, breathing pattern, and gas exchange in interstitial lung disease. Thorax 1992; 47: 93-97.
- LoRusso TJ, Belman MJ, Elashoff JD, Koerner SK. Prediction of maximal exercise capacity in obstructive and restrictive pulmonary disease. Chest 1993; 104: 1748-1754.
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Dysfunctional breathing: a review of the literature and proposal for classification
Boulding, R., Stacey, R., Niven, R., & Fowler, S. J. (2016) · European Respiratory Review · doi:10.1183/16000617.0088-2015 · Cited by 372 · see citing works
- Authors
- Kinnula, V. L., & Sovijärvi, A. R. A.
- Affiliations
- Helsinki University Hospital (FI)
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 90
- Issue
- 3
- Pages
- 145-151
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2014650130
- Cited by
- 19
- References
- 0
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- exercise-induced bronchoconstriction, mild asthma, hyperventilation syndrome, ventilatory equivalents, VO2max, sex differences, ventilatory capacity, FEV1
- MeSH terms
- Adult, Asthma, Exercise-Induced, Female, Forced Expiratory Volume, Humans, Hyperventilation, Lung, Male, Oxygen Consumption, Pulmonary Gas Exchange, Exercise, Bronchoconstriction
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