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Biogenesis of small nucleolar ribonucleoproteins
Abstract
Eukaryotic cells contain a very complex population of small nucleolar RNAs. They function, as small nucleolar ribonucleoproteins, in pre-ribosomal RNA processing reactions, and also guide methylation and pseudouridylation of ribosomal RNA, spliceosomal small nuclear RNAs, and possibly other cellular RNAs. Synthesis of small nucleolar RNAs frequently follows unusual strategies. Some newly discovered brain-specific small nucleolar RNAs of unknown function are encoded in introns of tandemly repeated units, expression of which is paternally imprinted. Recent studies of the protein components and factors participating in small nucleolar ribonucleoprotein assembly have revealed interesting connections with other classes of cellular ribonucleoproteins such as spliceosomal small nuclear ribonucleoproteins and telomerase. Cajal bodies emerge as nuclear structures important for the biogenesis and function of small nucleolar ribonucleoproteins.
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“a class of ncRNAs involved in the ribosomal RNA maturation and biogenesis [70]”
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Metadata
- Authors
- Filipowicz, W., & Pogačić, V.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Filipowicz, Witold
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 14
- Issue
- 3
- Pages
- 319-327
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2060678979
- Cited by
- 394
- References
- 81
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 12 · 2018: 17 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 18 · 2013: 10 · 2012: 13
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- small nucleolar ribonucleoproteins, pre-rRNA processing, ribosomal RNA methylation, pseudouridylation, small nuclear ribonucleoproteins, telomerase, Cajal bodies, paternal imprinting, ribonucleoprotein assembly
- MeSH terms
- Animals, Base Sequence, Brain, Cell Nucleolus, Models, Genetic, Nuclear Proteins, Ribonucleoproteins, RNA Processing, Post-Transcriptional, RNA, Small Nucleolar, Coiled Bodies
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