Gene regulation through messenger RNA stability
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Regulation of mRNA turnover plays a major role in the overall control of gene expression, and the mechanisms underlying steady-state levels of naturally expressed mRNAs in the cytoplasm have received considerable attention.
“The mechanisms underlying the steady state levels of naturally expressed mRNAs in the cytoplasm have received considerable attention recently because the regulation of mRNA turnover plays a major role in the overall control of gene expression.26,27”
From Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells (2006) · cites this paper as [27]
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Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527 · see citing works
Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625 · see citing works
- Authors
- Cleveland, D. W.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Cleveland, D.W.
- ORCID
- Cleveland, D.W.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1989-12
- Volume
- 1
- Issue
- 6
- Pages
- 1148-1153
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2064604926
- Cited by
- 43
- References
- 0
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- mRNA stability, dendritic cell vaccine, poly(A) tail length, 3' untranslated region, translation efficiency, tumor-associated antigen expression, antigen presentation, T cell stimulation
- MeSH terms
- Animals, Cell Cycle, Gene Expression Regulation, Histones, Hormones, Nucleic Acid Conformation, Proto-Oncogene Proteins, Receptors, Transferrin, Regulatory Sequences, Nucleic Acid, RNA Processing, Post-Transcriptional, RNA, Messenger, Tubulin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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