Mechanisms of asymmetric cell division during animal development
Abstract
Recent years have seen the discovery of machineries for asymmetric cell division in a number of different organisms. The Inscuteable protein is a central component of such a machinery in Drosophila. Within dividing Drosophila neural precursor cells, Inscuteable directs both the orientation of the mitotic spindle and the asymmetric segregation of the proteins Numb, Prospero and Miranda into one of the two daughter cells. Numb can act by repressing signalling via the transmembrane receptor Notch, whereas Miranda localizes the transcription factor Prospero which initiates daughter cell specific gene expression. The identification of Numb homologs in other species has suggested that this machinery might be conserved from Drosophila to vertebrates.
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Similar principles govern the asymmetric division of neuroblasts and ganglion mother cells, the precursors of glia and neurons.
“Analogous principles apply to the asymmetric cell division between neuroblasts and ganglion mother cells that give rise to glia and neurons (Anderson and Jan, 1997; Knoblich, 1997).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Knoblich, 1997
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References 53 · Cited by 87
- Authors
- Knoblich, J. A.
- Affiliations
- Research Institute of Molecular Pathology (AT)
- Corresponding author
- Knoblich, Juergen A
- ORCID
- Knoblich, Juergen A
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 9
- Issue
- 6
- Pages
- 833-841
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2008460479
- Cited by
- 87
- References
- 53
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 3 · 2016: 4 · 2015: 2 · 2013: 4 · 2012: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- asymmetric cell division, Inscuteable, Numb, Prospero, Miranda, Notch signaling, mitotic spindle orientation, neural progenitor cells, Drosophila, protein segregation
- MeSH terms
- Animals, Cell Division, Drosophila, Juvenile Hormones, Spindle Apparatus, Models, Biological, Nerve Tissue Proteins, Nervous System, Nuclear Proteins, RNA, Transcription Factors, Helminth Proteins, Cell Polarity, Caenorhabditis elegans, Drosophila Proteins, Caenorhabditis elegans Proteins, Mice
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