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CEA adhesion molecules: multifunctional proteins with signal-regulatory properties
Open accessAbstract
The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell—cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions.
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Citations
Cited by
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
Cavallaro, U., & Christofori, G. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1276 · Cited by 1,311
Beauchemin, N., & Arabzadeh, A. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9444-6 · Cited by 538
CEACAM1: contact-dependent control of immunity
Gray-Owen, S. D., & Blumberg, R. S. (2006) · Nature Reviews Immunology · doi:10.1038/nri1864 · Cited by 537
The Junctional Epithelium: from Health to Disease
Bosshardt, D. D., & Lang, N. P. (2005) · Journal of Dental Research · doi:10.1177/154405910508400102 · Cited by 388
CEACAMs: their role in physiology and pathophysiology
Kuespert, K., Pils, S., & Hauck, C. R. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.08.008 · Cited by 384
Metadata
- Authors
- Öbrink, B.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 9
- Issue
- 5
- Pages
- 616-626
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2044172471
- Cited by
- 284
- References
- 0
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- green
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