Cited by 534Cancer-related Molecular PathwaysTelomeres, Telomerase, and SenescenceChromatin Remodeling and Cancer

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The INK4A/ARF locus and its two gene products.

Sharpless, Norman E, DePinho, Ronald A·1999·Current Opinion in Genetics & Development

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Abstract

The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.

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Authors: Sharpless, N. E., & DePinho, R. A.
Affiliations: Dana-Farber Cancer Institute (US)
Corresponding author: DePinho, Ronald A
ORCID: Sharpless, Norman E
DePinho, Ronald A
Venue: Current Opinion in Genetics & Development
Publisher: Elsevier BV
Published: 1999-02
Volume: 9
Issue: 1
Pages: 22-30
ISSN: 0959-437X (ISSN-L)
DOI: 10.1016/s0959-437x(99)80004-5
OpenAlex: W1991595805
Cited by: 533
References: 92
Citations by year: 2026: 4 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 10 · 2021: 15 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 4 · 2016: 12 · 2015: 9 · 2014: 12 · 2013: 21 · 2012: 15
FWCI: 5.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Genetics & Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd028317-05, 7r01ey011267-04)
National Eye Institute (R01EY11267)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD28317)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: INK4a/ARF locus, p16INK4a, p19ARF, chromosome 9, tumor suppressor, cell cycle regulation, cellular senescence, cell growth, cell survival, cancer mutations
MeSH terms: Amino Acid Sequence, Humans, Molecular Sequence Data, Mutation, Neoplasms, Proteins, Genes, Tumor Suppressor, Sequence Homology, Amino Acid, Cyclin-Dependent Kinase Inhibitor p16, Genes, p16, Tumor Suppressor Protein p14ARF

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The INK4A/ARF locus and its two gene products.

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