The many faces of p75NTR
Abstract
The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new signaling partners, suggest that the numerous biological actions of the neurotrophins via p75(NTR) may reflect selectivity of ligand-receptor interactions and intracellular adaptor protein recruitment.
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Studies have shown that activation of p75NTR increases apoptotic and inflammatory signaling in neurons and glial cells by activation of c-Jun N-terminal kinases (JNK) and NF-κB expression, respectively.
“Studies have shown that activation of p75NTR increases apoptotic and inflammatory signaling in neurons and glial cells by activation of c-Jun N-terminal kinases (JNK) and NF-κB expression, respectively [32, 33].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [32]
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References 68 · Cited by 321
- Authors
- Hempstead, B.
- Affiliations
- Cornell University (US)
- Corresponding author
- Hempstead, B
- ORCID
- Hempstead, B
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2002-06-01
- Volume
- 12
- Issue
- 3
- Pages
- 260-267
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2065482131
- Cited by
- 321
- References
- 68
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 14 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 7 · 2014: 13 · 2013: 18 · 2012: 12
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- p75 neurotrophin receptor, neurotrophins, Trk receptors, receptor isoforms, ligand-receptor interactions, intracellular signaling, adaptor proteins, receptor signaling specificity
- MeSH terms
- Animals, Humans, Ligands, Signal Transduction, Receptors, Nerve Growth Factor, Receptor, Nerve Growth Factor
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