The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
Open accessAbstract
BACKGROUND: Chemokines are a family of proteins that chemoattract and activate immune cells by interacting with specific receptors on the surface of their targets. We have shown previously that chemokine receptors including the interleukin-8 receptor B (CXCR2) and the Duffy blood group antigen are expressed on subsets of neurons in various regions of the adult nervous system. RESULTS: Using a combination of immunohistochemical staining and receptor binding studies, we show that hNT cells, which are differentiated human neurons derived from the cell line NTera2, express functional chemokine receptors of the C-X-X and C-C types. These chemokine receptors include CXCR2, CXCR4, CCR1 and CCR5. We demonstrate high-affinity binding of both types of chemokines to hNT neurons and dose-dependent chemotactic responses to these chemokines in differentiated, but no t undifferentiated, NTera 2 cells. In addition, we show that the envelop glycoprotein from the T-cell-tropic human immunodeficiency virus 1 (HIV-1) strain IIIB is a CD4-independent, dose-dependent inhibitor of the binding of stromal cell-derived factor 1 to its receptor, CXCR4. CONCLUSIONS: These data support recent findings that members of the chemokine family, including CCR5 and LESTR/Fusin (CXCR4), function as coreceptors in combination with CD4 for HIV-1 invasion. This is the first report of functional expression of chemokine receptors on human neurons. Furthermore, our studies provide for direct CD4-independent association of the viral envelope protein of the HIV-1 strain III with the chemokine receptor CXCR4.
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Cites
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Self-citationHIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
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Cited by
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
Berger, E. A., Murphy, P. M., & Farber, J. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.657 · Cited by 2,180
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
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Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis
Kaul, M., & Lipton, S. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8212 · Cited by 512
Oh, S. B., Tran, P. B., Gillard, S. E., Hurley, R. W., Hammond, D. L., & Miller, R. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05027.2001 · Cited by 469
Metadata
- Authors
- Hesselgesser, J., Halks-Miller, M., DelVecchio, V., Peiper, S. C., Hoxie, J., Kolson, D. L., Taub, D., & Horuk, R.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 7
- Issue
- 2
- Pages
- 112-121
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2087343656
- Cited by
- 324
- References
- 43
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hesselgesser, J., Halks-Miller, M., DelVecchio, V., Peiper, S. C., Hoxie, J., Kolson, D. L., Taub, D., & Horuk, R. (1997). CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Current Biology. https://doi.org/10.1016/s0960-9822(06)00055-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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