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Cited by 313PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingDNA Repair Mechanisms

FAT: a novel domain in PIK-related kinases

Bosotti, Roberta, Isacchi, Antonella, Sonnhammer, Erik L.L.·2000·Trends in Biochemical Sciences
DOI 10.1016/s0968-0004(00)01563-2
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  • mTOR contains a FRAP, ATM and TRAPP (FAT) domain, a catalytic kinase domain and a C-terminal FATC domain found only in PIKKs.

    “Being one of the mammalian PI3K-related protein kinases (PIKKs), mTOR was known by sequence homology to contain a FRAP, ATM and TRAPP (FAT) domain, a catalytic kinase domain and a C-terminal ‘FATC ’ domain found only in PIKKs (Bosotti et al., 2000).”

    From Signal integration in the (m)TORC1 growth pathway (2018) · cites this paper as Bosotti et al., 2000

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References 24 · Cited by 313

Authors
Bosotti, R., Isacchi, A., & Sonnhammer, E. L. L.
Affiliations
  • Nerviano Medical Sciences (IT)
  • Karolinska Institutet (SE)
Corresponding author
Sonnhammer, Erik L.L.
ORCID
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2000-05
Volume
25
Issue
5
Pages
225-227
ISSN
0968-0004 (ISSN-L)
DOI
10.1016/s0968-0004(00)01563-2
OpenAlex
W1978754000
Cited by
313
References
24
Citations by year
2026: 3 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 14 · 2018: 18 · 2017: 10 · 2016: 6 · 2015: 8 · 2014: 19 · 2013: 8 · 2012: 10
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Biochemical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
FAT domain, phosphatidylinositol kinase, kinase domain, accessory domains, protein-protein interaction, sequence alignment, TRRAP, phosphoinositide signaling
MeSH terms
Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Sequence Homology, Amino Acid, Phosphatidylinositol 3-Kinases, 1-Phosphatidylinositol 4-Kinase

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