An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation.
Abstract
A method for construction and operation of an 225Ac/213Bi generator capable of producing 25-100 mCi of 213Bi suitable for clinical antibody labeling is described. The generator has been designed to have an effective lifetime of several weeks, producing up to six therapeutic doses of radionuclide per day. To date, 57 clinical doses have been prepared and injected into patients using the described 213Bi generator. Factors such as radiation damage, radioprotection, iodide eluate chemistry, radiolabeling chemistry and radionuclide purity are addressed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The short mean free path of 225Ac, together with the complexity and timing of its decay relative to radiopharmaceutical stability, uptake and clearance, makes measurement of 225Ac activity very difficult.
“The short mean free path of 225Ac (110), as well as the complexity and timing of 225Ac decay in relation to its radiopharmaceutical stability, uptake and clearance makes measurement of 225Ac activity very difficult.”
From Alpha-peptide receptor radionuclide therapy using actinium-225 labeled somatostatin receptor agonists and antagonists (2022) · cites this paper as [110]
The citation lists haven’t been fetched yet
References 10 · Cited by 138
- Authors
- McDevitt, M. R., Finn, R. D., Sgouros, G., Ma, D., & Scheinberg, D. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Scheinberg, David A.
- Venue
- Applied Radiation and Isotopes
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 50
- Issue
- 5
- Pages
- 895-904
- ISSN
- 0969-8043 (ISSN-L)
- OpenAlex
- W2072475957
- Cited by
- 138
- References
- 10
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 1 · 2016: 7 · 2014: 6 · 2013: 8 · 2012: 6
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Radiation and Isotopes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u01ca058260-02)
- National Cancer Institute (R01CA055349, P01CA033049, U01 CA58260)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Physical Sciences › Physics and Astronomy › Radiation › Radioactive Decay and Measurement Techniques
- Keywords
- 213Bi, actinium-225, radionuclide generator, antibody labeling, therapeutic radionuclides, radiation protection, radiation damage, radionuclidic purity
- MeSH terms
- Actinium, Alpha Particles, Bismuth, Isotope Labeling, Nuclear Medicine, Radioisotopes, Radionuclide Generators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
