The role of local estrogen Biosynthesis in males and females
Abstract
Natural (human) and experimental (mouse) models of estrogen insufficiency have revealed hitherto unexpected roles for estrogens in both males and females. In postmenopausal women, and in men, estrogen no longer has a major role as a circulating hormone, but rather it functions locally as a paracrine or even 'intracrine' factor in tissue sites where it is formed. As a consequence, the tissue-specific nature of aromatase production assumes physiological and pathophysiological significance. The availability of circulating precursors is also important in sites where there is no local supply of C19 precursors, particularly in elderly women. The potential clinical significance of these findings in terms of the development of new therapeutic modalities is discussed.
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Peripheral estrogen production often functions in a paracrine and intracrine manner and as such circulating concentrations are not reflective of the concentrations achieved locally.
“It should be noted that this peripheral estrogen production often functions in a paracrine and intracrine manner and as such circulating concentrations are not reflective of the concentrations achieved locally [304,305].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [304]
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References 52 · Cited by 249
- Authors
- Simpson, E., Rubin, G., Clyne, C., Robertson, K., O’Donnell, L., Jones, M., & Davis, S.
- Affiliations
- Jean Hailes (AU)
- Corresponding author
- Simpson, Evan
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 11
- Issue
- 5
- Pages
- 184-188
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2041591201
- Cited by
- 249
- References
- 52
- Citations by year
- 2025: 7 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 11 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 3 · 2012: 7
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AGO8174)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Keywords
- aromatase, paracrine signaling, intracrine signaling, postmenopausal women, men
- MeSH terms
- Adipose Tissue, Animals, Aromatase, Estrogens, Female, Humans, Male, Protein Precursors, Spermatogenesis, Testis
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