Mechanisms of Lipoapoptosis
Abstract
Accumulation of long-chain fatty acids in the heart has been proposed to play a role in the development of heart failure and diabetic cardiomyopathy. Several animal models with increased cardiomyocyte lipid accumulation suggest a link between the accumulation of lipid, cardiomyocyte cell death and the development of cardiomyopathy. In this review, we discuss the mechanism through which fatty acid accumulation may contribute to the development or progression of heart failure by initiation of apoptotic cell death. Long-chain saturated fatty acids induce apoptosis through a mechanism involving the generation of reactive intermediates. Reactive intermediate production occurs in concert with de novo ceramide synthesis, but ceramide production is not required for cell death. Cardiomyocyte dysfunction and death from reactive intermediates generated by long-chain saturated fatty acids may contribute to the pathogenesis of human heart disease.
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There is no evidence that triglyceride accumulation per se is damaging and it may represent an adaptive mechanism to sequester increased lipids, thereby representing a marker but not necessarily a mediator of lipotoxicity.
“There is no evidence that triglyceride accumulation per se is damaging and may represent an adaptive mechanism to sequester increased lipids, thereby representing a marker but not necessarily a mediator of lipotoxicity (214).”
From Cardiac remodeling in obesity (2008) · cites this paper as [214]
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References 45 · Cited by 123
- Authors
- Listenberger, L. L., & Schaffer, J. E.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Schaffer, Jean E
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 12
- Issue
- 3
- Pages
- 134-138
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W2084654917
- Cited by
- 123
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 12 · 2013: 4 · 2012: 4
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- lipoapoptosis, cardiomyocyte apoptosis, long-chain fatty acids, saturated fatty acids, heart failure, diabetic cardiomyopathy, reactive intermediates, ceramide synthesis, cardiomyocyte death
- MeSH terms
- Animals, Cell Line, Ceramides, Disease Models, Animal, Fatty Acids, Heart, Heart Diseases, Humans, Cardiomyopathies, Myocardium, Palmitates, Apoptosis, Reactive Oxygen Species, Lipid Metabolism, Mice
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