Diffuse axonal injuries: Pathophysiology and imaging
Abstract
Diffuse axonal shear injury is a common traumatic brain injury, with significant neurologic and behavioral impact on patients. Radiologic recognition of this entity and understanding of its sequelae can be of utmost importance in the prediction of outcome and planning for rehabilitation. MRI has proven to be the optimal means of detection and characterization of DAI lesions, with GRE and FLAIR sequences being particularly helpful, and more advanced techniques such as MRS show preliminary evidence of some utility in determining outcome.
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Disturbances of attention, memory, and executive functioning are the most common neurocognitive consequences associated with diffuse axonal injury.
“Disturbances of attention, memory, and executive functioning are the most common neurocognitive consequences associated with this process [14,15].”
From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [14]
The process of diffuse axonal injury explains much of the long-term cognitive dysfunction following TBI.
“The process of DAI explains much of the long term cognitive dysfunction following TBI [14].”
From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [14]
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References 41 · Cited by 132
- Authors
- Hammoud, D. A., & Wasserman, B. A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wasserman, Bruce A
- Venue
- Neuroimaging Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 12
- Issue
- 2
- Pages
- 205-216
- ISSN
- 1052-5149 (ISSN-L)
- OpenAlex
- W2039590340
- Cited by
- 132
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 10 · 2019: 3 · 2017: 5 · 2016: 7 · 2015: 9 · 2014: 2 · 2013: 4 · 2012: 6
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroimaging Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- diffuse axonal injury, traumatic brain injury, pathophysiology, MRI detection, gradient echo, FLAIR, magnetic resonance spectroscopy, outcome prediction, rehabilitation planning
- MeSH terms
- Brain, Humans, Magnetic Resonance Imaging, Prognosis, Tomography, X-Ray Computed, Diffuse Axonal Injury
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