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The role of reactive oxygen species in homeostasis and degradation of cartilage
Open accessAbstract
Objectives The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and growth factors, as well as mechanical stimuli, reactive oxygen species (ROS) emerge as major factors in this regulation. ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable.Method This review is focused on the role of ROS, mainly nitric oxide, peroxynitrite and superoxide anion radicals, in the signaling mechanisms implied in the main cellular functions, including synthesis and degradation of matrix components. The direct effects of ROS on cartilage matrix components as well as their inflammatory and immunomodulatory effects are also considered.Results Some intracellular signaling pathways are redox sensitive and ROS are involved in the regulation of the production of some biochemical factors involved in cartilage degradation and joint inflammation. Further, ROS may cause damage to all matrix components, either by a direct attack or indirectly by reducing matrix components synthesis, by inducing apoptosis or by activating latent metalloproteinases. Finally, we have highlighted the uncoupling effect of ROS on tissue remodeling and synovium inflammation, suggesting that antioxidant therapy could be helpful to treat structural changes but not to relieve symptoms.Conclusions This review of the literature supports the concept that ROS are not only deleterious agents involved in cartilage degradation, but that they also act as integral factors of intracellular signaling mechanisms. Further investigation is required to support the concept of antioxidant therapy in the management of joint diseases.
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“One disease whose aetiology is well known to be bound up with ROSs is rheumatoid arthritis (RA) [36,1241-1246].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1245]
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Cites
Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro
Abate, C., Patel, L., Rauscher, F. J., & Curran, T. (1990) · Science · doi:10.1126/science.2118682 · Cited by 1,573
Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation
Sauer, H., Wartenberg, M., & Hescheler, J. (2001) · Cellular Physiology and Biochemistry · doi:10.1159/000047804 · Cited by 1,118
Xanthoudakis, S., & Curran, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05097.x · Cited by 708
Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115929 · Cited by 686
Siwik, D. A., Pagano, P. J., & Colucci, W. S. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.1.c53 · Cited by 674
Chondrocyte apoptosis induced by nitric oxide.
Blanco, F. J., Ochs, R., Schwarz, H., & Lotz, M. (1995) · PubMed Central · Cited by 623
Lo, Y. Y. C., & Cruz, T. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11727 · Cited by 530
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide
Stadler, J., Stefanović-Račić, M., Billiar, T. R., CURRAN, R. D., McIntyre, L. A., Georgescu, H. I., Simmons, R. L., & Evans, C. H. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3915 · Cited by 438
Landino, L. M., Crews, B. C., Timmons, M. D., Morrow, J. D., & Marnett, L. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15069 · Cited by 423
Nitric Oxide Activates Metalloprotease Enzymes in Articular Cartilage
Murrell, G. A. C., Jang, D., & Williams, R. J. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1003 · Cited by 407
Research works printed but not linked: 1
- Henrotin, 2002, Type II collagen derived fragment (Coll2-1) is a new marker predictive of osteoarthritic progression, Osteoporos Int, 13, S17
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Items 701–740 of 740
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Xu, C., Meng, L., Xiao, Y., Qiu, Y., Du, Y.-J., Huang, C., & Wang, F. (2020) · doi:10.21203/rs.3.rs-31843/v1
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Gosset, M., Sellam, J., Jacques, C., & Berenbaum, F. (2012) · Chemical biology · doi:10.1002/9781118435762.ch15
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Galleguillos, M., Lemaitre, M., Letelier, M., & Adarmes, H. (2010) · Avances en Ciencias Veterinarias · doi:10.5354/0716-260x.2007.917
Heluany, C. S., Palma, A. D., Day, N. J., Farsky, S. P., & Nalesso, G. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.02.217
Binard, A., & Saraux, A. (2006) · EMC - Appareil locomoteur · doi:10.1016/s0246-0521(06)40623-9
Gosset, M., Sellam, J., Jacques, C., & Berenbaum, F. (2009) · Wiley eBooks · doi:10.1002/9780470048672.wecb684
Binard, A., & Saraux, A. (2006) · EMC - Aparato Locomotor · doi:10.1016/s1286-935x(06)46541-2
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Pierre-Jerome, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99352-4.00025-5
Wang, P., Zhang, Y., Dong, K., Lei, H., Zhou, Q., Yu, J., Shi, X., Zhu, Y., Zhang, P., Xing, J., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1924296/v1
Hamidy, A. A., Alosami, M. H., & Hamzah, M. I. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.04.014
Yudoh, K., Yui, N., Kumai, T., Kobayashi, H., Toshikazu, K., Fujiya, H., 木城智, Uehara, K., & Niki, H. (2018) · doi:10.19080/ntab.2018.03.555601
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Sanyal, P. D. S. (2024) · International Journal of Science and Research (IJSR) · doi:10.21275/sr24402100259
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Melia, F., Udomjarumanee, P., Rogoyski, R., & Pranjol, M. Z. I. (2025) · Springer eBooks · doi:10.1007/978-3-032-00773-5_412
Bingül, İ., Koç, B., Hanikoglu, A., Delen, E., Ömer, B., Genç, S., & Zülfikar, B. (2025) · Indian Journal of Hematology and Blood Transfusion · doi:10.1007/s12288-025-02211-8
Rashidi, A. H., Bastan, M., Golestani, A., Azadnajafabad, S., Rezaei, N., Zeinodinimeymand, M., Busehail, M. J., Yaqoob, M., Heidari‐Foroozan, M., & Rashidi, M. (2025) · Clinical Rheumatology · doi:10.1007/s10067-025-07761-w
Uituke, H., Maciel, D. M., Prieto, G. R., Kazedani, S. A., Cola, P. C., & Herculiani, C. E. (2025) · Revista de Epidemiologia e Saúde Pública - RESP · doi:10.59788/resp.v3i1.214
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Gigout, A., Harazin, D., Topping, L. M., Merciris, D., Lindemann, S., Brenneis, C., & Nissim, A. (2021) · Figshare · doi:10.6084/m9.figshare.14418089
La, R., Zhou, L., Yin, Y., Lu, L., Li, L., Jiang, D., Huang, L., & Wu, Q. (2024) · Figshare · doi:10.6084/m9.figshare.25558975
La, R., Zhou, L., Yin, Y., Lu, L., Li, L., Jiang, D., Huang, L., & Wu, Q. (2024) · Figshare · doi:10.6084/m9.figshare.25558927
Singhai, A., & Patil, U. K. (2021) · Figshare · doi:10.6084/m9.figshare.13633022
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Drevet, S. (2020) · theses.fr (ABES) · doi:10.70675/336e1eabz92c2z463cza33cz5d08cd35f9ab
Synthesis and Antitumor Activity of Novel Amino Glucose Derivative Schiff Base Copper(II) Complexes
Chunyan, G., Xinyue, C., Kaiyue, W., Xueyi, S., Qing, H., Zhao, J., Aiqin, Y., Weijun, D., & Zhang, Y. (2026) · 化学学报 · doi:10.6023/a25090314
Novikova, L. A., Dontsova, E. V., Kuranosov, A. Y., Борзунова, Л. Н., Игоревна, О. Н., Bamet'ev, A. A., & В., К. А. (2026) · Clinical Medicine (Russian Journal) · doi:10.30629/0023-2149-2026-104-2-117-121
Amirkhizi, F., Mercantepe, F., Shahraki, S. H., & Klisic, A. N. (2026) · Biomarkers in Medicine · doi:10.1080/17520363.2026.2692040
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Mastroeni, P., Trezza, A., Visibelli, A., Geminiani, M., & Santucci, A. (2026) · Antioxidants · doi:10.3390/antiox15070823
Yan, C., Gu, X.-Y., Mao, J.-H., Mei, A.-Y., Sun, J., Kurihara, H., Li, Y.-F., He, R., Sun, P.-H., & Li, W.-X. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.103133
Xu, B., Dou, J., Wu, Y., Deng, Y., Wang, L., Wang, X., Yang, G., & Xie, D. (2026) · Medicine · doi:10.1097/md.0000000000049453
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Dong, H., Zhang, X., Luo, Y., Jin, J., Luo, Z., & 吕雅丽 (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117141
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Rehman, A., Jamil, M., Farhan, M., Khan, A. S., Javaid, M., Iftikhar, A., & Malik, U. U. (2026) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.42.8.14392
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LeBlanc, R., Valls, M., Fornabaio, G., Ginebra, M., Espona‐Noguera, A., Tampieri, F., & Canal, C. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.215118
Mo, D., Wen, Y., Cheng, C., Chen, X., Sun, Q., Zhang, H., An, X., Liu, W., Cui, X., Zhang, Y., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c15540
Ma, Z., Wang, W., Chen, Y., Lin, Z., Wu, F., Gao, Y., Li, Z., & Honghai, Z. H. O. U. (2026) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2026.100598
Ye, Z., Zhu, M., Dai, F., & Zhou, Z. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.115197
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Sun, H., & Yu, H. (2026) · Regenerative Therapy · doi:10.1016/j.reth.2026.101195
Metadata
- Authors
- Henrotin, Y. E., Bruckner, P., & Pujol, J.-P. L.
- Affiliations
- University of Liège (BE)
- Université de Caen Normandie (FR)
- Corresponding author
- Henrotin, Y.E
- ORCID
- Henrotin, Y.E
- Venue
- Osteoarthritis and Cartilage
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 11
- Issue
- 10
- Pages
- 747-755
- ISSN
- 1063-4584 (ISSN-L)
- OpenAlex
- W2044924856
- Cited by
- 740
- References
- 82
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 30 · 2023: 35 · 2022: 34 · 2021: 37 · 2020: 39 · 2019: 35 · 2018: 45 · 2017: 36 · 2016: 32 · 2015: 33 · 2014: 35 · 2013: 34 · 2012: 45
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Osteoarthritis and Cartilage (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- Funders
- UCB Pharma
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, cartilage degeneration, cartilage homeostasis, nitric oxide, peroxynitrite, superoxide, redox signaling, joint inflammation, synovium, matrix metalloproteinases, apoptosis, antioxidant therapy, osteoarthritis, rheumatoid arthritis
- MeSH terms
- Cartilage, Articular, Extracellular Matrix, Homeostasis, Humans, Osteoarthritis, Oxidation-Reduction, Synovial Membrane, Signal Transduction, Cytokines, Apoptosis, Reactive Oxygen Species, Chondrocytes, Metalloproteases
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