The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
Open accessAbstract
The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation. Constitutive expression of Pim-1 together with c-myc, another STAT3 target, fully compensated for loss of the STAT3-mediated cell cycle progression, antiapoptosis, and bcl-2 expression. We also identified valosine-containing protein (VCP) as a target gene for the Pim-1-mediated signal. Expression of a mutant VCP led cells to undergo apoptosis. These results indicate that Pim-family proteins play crucial roles in gp130-mediated cell proliferation and explain the synergy between Pim and c-Myc proteins in cell proliferation and lymphomagenesis.
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Cites
Essential role of Stat6 in IL-4 signalling
Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature · doi:10.1038/380627a0 · Cited by 1,557
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
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Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584
Hilbert, D. M., Migone, T.-S., Kopf, M., Leonard, W. J., & Rudikoff, S. (1996) · Immunity · doi:10.1016/s1074-7613(00)80312-x · Cited by 40 · cited 1×
“Upon stimulation by these et al., 1995; Hilbert et al., 1996; Migone et al., 1995;cytokines, gp130 forms a homodimer and activates the Turkson et al., 1998; Yu et al., 1995).”
Background
Cited by
Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
“STAT3 is involved not only in bcl-2 induction, but also in the induction of c-myc, cyclins and Pim1/2 kinase to regulate cell survival and cell cycle progression in a pre-B-cell line (110, 126, 127).”
BackgroundSelf-citationHypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
Pasqualucci, L., Neumeister, P., Goossens, T., Nanjangud, G., Chaganti, R. S. K., Küppers, R., & Dalla-Favera, R. (2001) · Nature · doi:10.1038/35085588 · Cited by 1,032
A Caspase-Related Protease Regulates Apoptosis in Yeast
Madeo, F., Herker, E., Maldener, C., Wissing, S., Lächelt, S., Herlan, M., Fehr, M., Lauber, K., Sigrist, S. J., Wesselborg, S., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00501-4 · Cited by 872
Multiple myeloma: evolving genetic events and host interactions
Kuehl, W. M., & Bergsagel, P. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc746 · Cited by 818
Metadata
- Authors
- Shirogane, T., Fukada, T., Muller, J. M. M., Shima, D. T., Hibi, M., & Hirano, T.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 11
- Issue
- 6
- Pages
- 709-719
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1968631842
- Cited by
- 426
- References
- 4
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80145-4
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- Shirogane, T., Fukada, T., Muller, J. M. M., Shima, D. T., Hibi, M., & Hirano, T. (1999). Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis. Immunity. https://doi.org/10.1016/s1074-7613(00)80145-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
