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Identification of the Earliest B Lineage Stage in Mouse Bone Marrow
Open accessAbstract
We have identified a very early stage of B lineage cells in the CD45R (B220)+CD24 (HSA) pre-pro-B fraction of mouse bone marrow delineated by expression of AA4.1, a molecule found on stem cells and early B lineage cells. These cells are B lineage precursors based on their capacity to generate B lineage cells rapidly in stromal-dependent culture and their expression of high levels of germline IgH transcripts in the absence of Rag-1/2. Half of these AA4.1+ precursors express low levels of CD4, characteristic of lymphoid progenitors, but few if any have up-regulated CD19, a molecule expressed very early in the B lineage. Furthermore, expression of genes encoding pre-B and B cell receptor components (mb-1, B29, and lambda 5) and transcription factors necessary for B lineage differentiation (BSAP, E12, E47, and Id) provide further support for designating these cells as the earliest B cell precursors.
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Han, H., Tanigaki, K., Yamamoto, N., Kuroda, K., Yoshimoto, M., Nakahata, T., Ikuta, K., & Honjo, T. (2002) · International Immunology · doi:10.1093/intimm/dxf030 · Cited by 587
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Bichi, R., Shinton, S. A., Martin, E. S., Koval, A., Calin, G. A., Cesari, R., Russo, G., Hardy, R. R., & Croce, C. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102181599 · Cited by 582
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Metadata
- Authors
- Li, Y.-S., Wasserman, R., Hayakawa, K., & Hardy, R. R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 5
- Issue
- 6
- Pages
- 527-535
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1996418577
- Cited by
- 376
- References
- 0
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Li, Y.-S., Wasserman, R., Hayakawa, K., & Hardy, R. R. (1996). Identification of the Earliest B Lineage Stage in Mouse Bone Marrow. Immunity. https://doi.org/10.1016/s1074-7613(00)80268-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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