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EBV Persistence in Memory B Cells In Vivo
Open accessAbstract
Epstein-Barr virus establishes latency in vitro by activating human B cells to become proliferating blasts, but in vivo it is benign. In the peripheral blood, the virus resides latently in resting B cells that we now show are restricted to the sIgD memory subset. However, in tonsils the virus shows no such restriction. We propose that EBV indiscriminately infects B cells in mucosal lymphoid tissue and that these cells differentiate to become resting memory B cells that then enter the circulation. Activation to the blastoid stage of latency is an essential intermediate step in this process. Thus, EBV may persist by exploiting the mechanisms that produce and maintain long-term B cell memory.
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Cited by
Functional delivery of viral miRNAs via exosomes
Pegtel, D. M., Cosmopoulos, K., Thorley-Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Würdinger, T., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,641
Self-citationCohen, J. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430707 · Cited by 1,636
Epstein-Barr virus: exploiting the immune system
Thorley-Lawson, D. A. (2001) · Nature Reviews Immunology · doi:10.1038/35095584 · Cited by 939
Self-citationThompson, M. P., & Kurzrock, R. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0670-3 · Cited by 786
Plottel, C. S., & Blaser, M. J. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.003 · Cited by 743
Metadata
- Authors
- Babcock, G. J., Decker, L. L., Volk, M., & Thorley-Lawson, D. A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 9
- Issue
- 3
- Pages
- 395-404
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2074795687
- Cited by
- 825
- References
- 0
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: EBV Persistence in Memory B Cells In Vivo. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80622-6
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- Babcock, G. J., Decker, L. L., Volk, M., & Thorley-Lawson, D. A. (1998). EBV Persistence in Memory B Cells In Vivo. Immunity. https://doi.org/10.1016/s1074-7613(00)80622-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
