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Epstein–Barr Virus Coopts Lipid Rafts to Block the Signaling and Antigen Transport Functions of the BCR
Open accessAbstract
The B cell antigen receptor (BCR) functions to initiate signaling and to internalize antigen for processing from within Lyn kinase-enriched membrane lipid rafts. The signaling function of the BCR is blocked by Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A), which is constitutively phosphorylated by Lyn. Here, we show that LMP2A resides in lipid rafts and excludes the BCR from entering rafts by Lyndependent mechanisms, thus blocking both BCR signaling and antigen transport. Mutant LMP2A that permits BCR signaling and raft translocation still blocks antigen trafficking, indicating independent control of these BCR functions. Thus, EBV coopts the lipid rafts to disarm both the signaling and antigen-processing functions of the BCR by independent mechanisms.
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Citations
Cited by
Roles of lipid rafts in membrane transport
Ikonen, E. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00238-6 · Cited by 629
Location is Everything: Lipid Rafts and Immune Cell Signaling
Dykstra, M., Cherukuri, A., Sohn, H. W., Tzeng, S.-J., & Pierce, S. K. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141021 · Cited by 477
Self-citationDawson, C. W., Port, R. J., & Young, L. S. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.01.004 · Cited by 355
Infectious agents and cancer: criteria for a causal relation
Pagano, J. S., Blaser, M., Buendia, M.-A., Damania, B., Khalili, K., Raab-Traub, N., & Roizman, B. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.009 · Cited by 337
Kwakkenbos, M. J., Diehl, S. A., Yasuda, E., Bakker, A. Q., van Geelen, C. M. M., Lukens, M. V., van Bleek, G. M., Widjojoatmodjo, M. N., Bogers, W. M. J. M., Mei, H., et al. (2010) · Nature Medicine · doi:10.1038/nm.2071 · Cited by 300
Metadata
- Authors
- Dykstra, M. L., Longnecker, R., & Pierce, S. K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 14
- Issue
- 1
- Pages
- 57-67
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2093049001
- Cited by
- 161
- References
- 0
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dykstra, M. L., Longnecker, R., & Pierce, S. K. (2001). Epstein–Barr Virus Coopts Lipid Rafts to Block the Signaling and Antigen Transport Functions of the BCR. Immunity. https://doi.org/10.1016/s1074-7613(01)00089-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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