WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
Open accessAbstract
WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors. The physiological role of WSX-1, which is expressed mainly in T cells, was investigated in gene-targeted WSX-1-deficient mice. IFN-gamma production was reduced in isolated WSX-1(-/-) T cells subjected to primary stimulation in vitro to induce Th1 differentiation but was normal in fully differentiated and activated WSX-1(-/-) Th1 cells that had received secondary stimulation. WSX-1(-/-) mice were remarkably susceptible to Leishmania major infection, showing impaired IFN-gamma production early in the infection. However, IFN-gamma production during the later phases of the infection was not impaired in the knockout. WSX-1(-/-) mice also showed poorly differentiated granulomas with dispersed accumulations of mononuclear cells when infected with bacillus Calmette-Guerin (BCG). Thus, WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance.
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Knockout of the IL-27 receptor increases susceptibility of mice to bacterial and parasitic infections due to impaired IFN-γ production.
“Knockout of its receptor ensues in increased susceptibility of mice to bacterial and parasitic infections due to impaired IFN-γ production (56).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [56]
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Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708 · see citing works
“Knockout of its receptor ensues in increased susceptibility of mice to bacterial and parasitic infections due to impaired IFN-γ production (56).”
BackgroundStumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology · doi:10.1038/ni1376 · Cited by 955 · see citing works
Self-citationPleiotropy and specificity: insights from the interleukin 6 family of cytokines
Murakami, M., Kamimura, D., & Hirano, T. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.027 · Cited by 533 · see citing works
Dong, Z., Lu, X., Yang, Y., Zhang, T., Li, Y., Chai, Y., Lei, W., Li, C., Ai, L., & Tai, W. (2015) · BMC Pulmonary Medicine · doi:10.1186/s12890-015-0012-4 · Cited by 42 · see citing works
- Authors
- Yoshida, H., Hamano, S., Senaldi, G., Covey, T., Faggioni, R., Mu, S., Xia, M., Wakeham, A. C., Nishina, H., Potter, J., Saris, C. J. M., & Mak, T. W.
- Affiliations
- Kyushu University (JP)
- Amgen (United States) (US)
- University of Toronto (CA)
- Corresponding author
- Mak, Tak W
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 15
- Issue
- 4
- Pages
- 569-578
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2057522151
- Cited by
- 406
- References
- 0
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 14 · 2021: 14 · 2020: 16 · 2019: 10 · 2018: 10 · 2017: 7 · 2016: 23 · 2015: 14 · 2014: 16 · 2013: 23 · 2012: 17
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- WSX-1, IL-12 receptor, Th1 differentiation, IFN-gamma production, granuloma formation, BCG infection, T cell activation, cytokine receptors
- MeSH terms
- Animals, Cell Differentiation, Cell Division, Cells, Cultured, Granuloma, Hematopoietic System, Interferon-gamma, Lymphatic System, Mycobacterium bovis, RNA, Messenger, Tuberculosis, Interleukin-4, Leishmaniasis, Cutaneous, Receptors, Cytokine, Receptors, Interleukin, Leishmania major, Mice, Knockout, Th1 Cells, Mice
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