IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo
Open accessAbstract
We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion of mice with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The induction of these cytokines resulted in Th2-like responses marked by increased serum IgE, IgG(1), and IgA levels, blood eosinophilia, and pathological changes in the lungs and digestive tract that included eosinophilic infiltrates, increased mucus production, and epithelial cell hyperplasia/hypertrophy. In addition, our studies show that IL-25 induces Th2-type cytokine production by accessory cells that are MHC class II(high), CD11c(dull), and lineage(-). These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types.
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IL-25 activates ILC2 cells.
“IL-25 was found to activate a population of lineage negative cells subsequently identified as ILC2”
From The IL-17 Family of Cytokines in Health and Disease (2019) · cites this paper as Fort et al., 2001
IL-25 uniquely induces IL-4, IL-5, IL-13, and TSLP, which are associated with type 2 immunity.
“IL-25 uniquely induces expression of IL-4, IL-5, IL-13, and TSLP, all associated with type 2 immunity”
From The IL-17 Family of Cytokines in Health and Disease (2019) · cites this paper as Fort et al., 2001
By interfering with IFN production, respiratory viruses can block multiple antiviral pathways simultaneously, including IFN synthesis, ISG induction, and recruitment of inflammatory cells.
“By interfering with IFN production, respiratory viruses can block multiple antiviral pathways simultaneously, including IFN synthesis, ISG induction, and recruitment of inflammatory cells (71, 226).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [71]
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References 39 · Cited by 1,203
Research works printed but not linked: 5
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- Authors
- Fort, M. M., Cheung, J., Yen, D., Li, J., Zurawski, S. M., Lo, S., Menon, S., Clifford, T., Hunte, B., Lesley, R., Muchamuel, T., Hurst, S. D., Zurawski, G., Leach, M. W., Gorman, D. M., & Rennick, D. M.
- Corresponding author
- Rennick, Donna M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 15
- Issue
- 6
- Pages
- 985-995
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2050604953
- Cited by
- 1,203
- References
- 39
- Citations by year
- 2026: 18 · 2025: 39 · 2024: 34 · 2023: 37 · 2022: 50 · 2021: 59 · 2020: 52 · 2019: 62 · 2018: 60 · 2017: 66 · 2016: 85 · 2015: 78 · 2014: 86 · 2013: 80 · 2012: 75
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- IL-25, IL-4, IL-5, IL-13, Th2 cells, eosinophilia, serum IgE, IgG1, IgA, eosinophilic inflammation, mucus production, epithelial hyperplasia, allergic inflammation, cytokine amplification
- MeSH terms
- Amino Acid Sequence, Animals, Histocompatibility Antigens Class II, Cells, Cultured, Cloning, Molecular, DNA-Binding Proteins, Eosinophilia, Gastric Mucosa, Gastrointestinal Diseases, Gene Expression Regulation, Growth Substances, Humans, Hypergammaglobulinemia, Hyperplasia, Hypertrophy, Interleukins, Intestinal Mucosa, Lung, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, Nuclear Proteins, Pulmonary Eosinophilia, RNA, Messenger, Interleukin-4, Interleukin-5, Integrin alphaXbeta2, T-Lymphocyte Subsets, Sequence Alignment, Sequence Homology, Amino Acid, Mice, Knockout, Th2 Cells, Interleukin-13, Cell Lineage, Receptors, Interleukin-4, Interleukin-17, Mice
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