CoChat
Sign Up
Cited by 102Allergic Rhinitis and SensitizationAsthma and respiratory diseasesFood Allergy and Anaphylaxis Research

The DOI matches its Crossref record.

The role of antileukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials

Rodrigo, Gustavo J., Yañez, Anahi·2006·Annals of Allergy, Asthma & Immunology
DOI 10.1016/s1081-1206(10)61339-7
Open this paper in CoChat — free account

Abstract

Objective To evaluate the effect of oral leukotriene receptor antagonists as monotherapy or combined with other drugs in the treatment of seasonal allergic rhinitis. Data sources The MEDLINE, EMBASE, CINAHL (Cumulative Index to Nursing and Allied Health), and Cochrane databases; review articles; and references of included trials. Study selection Published (1966-2005) randomized controlled trials with nasal and eye symptoms and quality-of-life scores as primary outcomes. Results Seventeen studies including 6,231 adults with seasonal allergic rhinitis were selected. Oral leukotriene antagonists significantly reduced daytime nasal symptoms (standardized mean difference [SMD], -0.24; 95% confidence interval [CI], -0.33 to -0.16), nighttime nasal symptoms (SMD, -0.23; 95% CI, -0.30 to -0.16), and eye symptoms and significantly improved quality of life compared with placebo. There were no significant differences between oral leukotriene antagonists and oral histamine H1 antagonists on nasal and eye symptoms and quality-of-life overall score. We also found that leukotriene receptor antagonists were inferior to intranasal corticosteroids for decreasing daytime (SMD, 0.41; 95% CI, 0.27 to 0.56) and nighttime nasal symptoms. The combination of leukotriene receptor antagonists plus histamine H1 antagonists produced greater relief of eye symptoms compared with histamine H1 antagonists alone. Finally, intranasal corticosteroids significantly reduced nasal congestion compared with leukotri…

Overview

Integrity signals

Registry

Crossref · 10.1016/s1081-1206(10)61339-7

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 30

  1. Nathan, 1997, Prevalence of allergic rhinitis in the United States, J Allergy Clin Immunol, 99, S808, 10.1016/S0091-6749(97)80040-1 · DOI · Paper page
  2. Bousquet, 2001, Allergic rhinitis and its impact its impact on asthma, J Allergy Clin Immunol, 108, S147, 10.1067/mai.2001.118891 · DOI · Paper page
  3. van Cauwenberge, 2000, Consensus statement on the treatment of allergic rhinitis, Allergy, 55, 116, 10.1034/j.1398-9995.2000.00526.x · DOI
  4. Weiner, 1997, Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials, BMJ, 317, 1624, 10.1136/bmj.317.7173.1624 · DOI · Paper page
  5. Yañez, 2002, Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis, Ann Allergy Asthma Immunol, 89, 479, 10.1016/S1081-1206(10)62085-6 · DOI
  6. Busse, 1996, The role of leukotriene in asthma and allergic rhinitis, Clin Exp Allergy, 26, 868, 10.1111/j.1365-2222.1996.tb00621.x · DOI
  7. Lipworth, 2001, Emerging role of antileukotriene therapy in allergic rhinitis, Clin Exp Allergy, 31, 1813, 10.1046/j.1365-2222.2001.01202.x · DOI
  8. Meltzer, 2002, Clinical evidence for antileukotriene therapy in the management of allergic rhinitis, Ann Allergy Asthma Immunol, 88, 23, 10.1016/S1081-1206(10)62025-X · DOI
  9. Nathan, 2003, Pharmacotherapy for allergic rhinitis: a critical review of leukotriene receptor antagonists compared with other treatments, Ann Allergy Asthma Immunol, 90, 182, 10.1016/S1081-1206(10)62138-2 · DOI
  10. Jadad, 1995, Assessing the quality of reports of randomized controlled trials: is blinding necessary?, Control Clin Trials, 134, 1
  11. DerSimonian, 1986, Meta-analysis in clinical trials, Control Clin Trials, 7, 177, 10.1016/0197-2456(86)90046-2 · DOI · Paper page
  12. Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557 · DOI · Paper page
  13. Pullerits, 1999, Randomized placebocontrolled study comparing a leukotriene receptor antagonist and a nasal glucocorticoid in seasonal allergic rhinitis, Am J Respir Crit Care Med, 159, 1814, 10.1164/ajrccm.159.6.9810016 · DOI
  14. Meltzer, 2000, Concomitant montelukast and loratadine as treatment for seasonal allergic rhinitis: a randomized, placebocontrolled clinical trial, J Allergy Clin Immunol, 105, 917, 10.1067/mai.2000.106040 · DOI
  15. Wilson, 2000, Evaluation of treatment response in patients with seasonal allergic rhinitis using domiciliary nasal peak inspiratory flow, Clin Exp Allergy, 30, 833, 10.1046/j.1365-2222.2000.00749.x · DOI
  16. Wilson, 2001, Effects of monotherapy with intranasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis, Clin Exp All, 31, 61, 10.1111/j.1365-2222.2001.00964.x · DOI
  17. Wilson, 2001, Effects of topical corticosteroid and combined mediator blockade on domiciliary and laboratory measurements of nasal function in seasonal allergic rhinitis, Ann Allergy Asthma Immunol, 87, 344, 10.1016/S1081-1206(10)62250-8 · DOI
  18. Nayak, 2002, Efficacy and tolerability of montelukast alone or in combination with loratadine in seasonal allergic rhinitis: a multicenter, randomized, double-blind, placebocontrolled trial performed in the fall, Ann Allergy Asthma Immunol, 88, 592, 10.1016/S1081-1206(10)61891-1 · DOI
  19. Philip, 2002, Montelukast for treating seasonal allergic rhinitis: a randomized, double-blind, placebocontrolled trial performed in the spring, Clin Exp Allergy, 32, 1020, 10.1046/j.1365-2222.2002.01422.x · DOI
  20. Pullerits, 2002, Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis, J Allergy Clin Immunol, 109, 949, 10.1067/mai.2002.124467 · DOI
  21. Wilson, 2002, A comparison of once daily fexofenadine versus the combination of montelukast plus loratadine on domiciliary nasal peak flow and symptoms in seasonal allergic rhinitis, Clin Exp Allergy, 32, 126, 10.1046/j.0022-0477.2001.01252.x · DOI
  22. Ratner, 2003, Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast, Ann Allergy Asthma Immunol, 90, 536, 10.1016/S1081-1206(10)61847-9 · DOI
  23. Saengpanich, 2003, Fluticasone nasal spray and the combination of loratadine and montelukast in seasonal allergic rhinitis, Arch Otolaryngol Head Neck Surg, 129, 557, 10.1001/archotol.129.5.557 · DOI
  24. Van Adelsberg, 2003, Randomized controlled trial evaluating the clinical benefit of montelukast for treating spring seasonal allergic rhinitis, Ann Allergy Asthma Immunol, 90, 214, 10.1016/S1081-1206(10)62144-8 · DOI
  25. Van Adelsberg, 2003, Montelukast improves symptoms of seasonal allergic rhinitis over a 4-week treatment period, Allergy, 58, 1268, 10.1046/j.1398-9995.2003.00261.x · DOI
  26. Ciprandi, 2004, Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: histamine and leukotriene antagonism, Allerg Immunol (Paris), 36, 67
  27. Di Lorenzo, 2004, Randomized placebocontrolled trial comparing fluticasone aqueous nasal spray in monotherapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis, Clin Exp Allergy, 34, 259, 10.1111/j.1365-2222.2004.01877.x · DOI
  28. Kurowski, 2004, Montelukast plus cetirizine in the prophylactic treatment of seasonal allergic rhinitis: influence on clinical symptoms and nasal allergic inflammation, Allergy, 59, 280, 10.1046/j.1398-9995.2003.00416.x · DOI
  29. Moinuddin, 2004, Comparison of the combination of fexofenadine-pseudoephedrine and loratadinemontelukast in the treatment of seasonal allergic rhinitis, Ann Allergy Asthma Immunol, 92, 73, 10.1016/S1081-1206(10)61713-9 · DOI
  30. Moher, 1999, Improving the quality of reports of meta-analyses of randomized controlled trials: the QUOROM statement, Lancet, 354, 1896, 10.1016/S0140-6736(99)04149-5 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Rodrigo, G. J., & Yañez, A.
Affiliations
Hospital Central de las Fuerzas Armadas (UY)
Corresponding author
Rodrigo, Gustavo J.
ORCID
Rodrigo, Gustavo J.
Venue
Annals of Allergy, Asthma & Immunology
Publisher
Elsevier BV
Published
2006-06
Volume
96
Issue
6
Pages
779-786
ISSN
1081-1206 (ISSN-L)
DOI
10.1016/s1081-1206(10)61339-7
OpenAlex
W2004515342
Cited by
102
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 19 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 9 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 6
FWCI
0.79
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Annals of Allergy Asthma & Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
allergic rhinitis, leukotriene receptor antagonists, antileukotriene therapy, histamine H1 receptor antagonists, intranasal corticosteroids, combination therapy, nasal symptoms, ocular symptoms, quality of life, nasal congestion
MeSH terms
Administration, Intranasal, Administration, Oral, Adrenal Cortex Hormones, Rhinitis, Allergic, Seasonal, Histamine H1 Antagonists, Humans, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Leukotriene Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review