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Cited by 22Retinoids in leukemia and cellular processesAntioxidant Activity and Oxidative StressAnimal Nutrition and Physiology

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Plasma transport and tissue distribution of β-carotene, vitamin A and retinol-binding protein in domestic cats

Raila, Jens, Mathews, Una, Schweigert, Florian J.·2001·Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
DOI 10.1016/s1095-6433(01)00443-3
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Abstract

The objective of this study was to determine retinol, retinyl esters and retinol-binding protein (RBP) as well as carotenoids in plasma, urine, liver and kidneys of randomly selected domestic cats. Retinol (240+/-64 ng/ml, mean+/-S.D.) represented one-third of total retinyl esters (736+/-460 ng/ml) in plasma. Retinyl esters were stearate, palmitate and oleate representing 61+/-6, 36+/-13 and 5+/-3% of total retinyl esters, respectively. In half of the cats, retinyl esters (22+/-21 ng/ml) were found in the urine. Vitamin A in the livers (4317+/-1956 microg/g) was significantly higher than in the kidney cortex and medulla (14.16+/-8.92 and 7.59+/-4.52 microg/g, respectively, both P<0.001). RBP was detected in the plasma but not in the urine. Immunoreactive RBP was observed in hepatocytes and in the cells of the proximal tubules. beta-Carotene was present in plasma but never in tissues. The results show that similar to canines differences in vitamin A metabolism in cats are related to the occurrence of retinyl esters in plasma. They differ, however, with regard to the tissue distribution of beta-carotene and the excretion of vitamin A in the urine.

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Crossref · 10.1016/s1095-6433(01)00443-3

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  • In fasting dogs, cats, and ferrets, the dominant form of retinoid is not retinol but rather REs.

    “Studies on domesticated carnivores indicated that unlike in human, mouse, and rats the dominant form of retinoid in fasting dogs, cats, and ferrets is not retinol but rather REs [122,123,124].”

    From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [123]

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Research works printed but not linked: 33

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Metadata

Authors
Raila, J., Mathews, U., & Schweigert, F. J.
Affiliations
University of Potsdam (DE)
Corresponding author
Raila, Jens
ORCID
Raila, Jens
Venue
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Publisher
Elsevier BV
Published
2001-11
Volume
130
Issue
4
Pages
849-856
ISSN
1095-6433 (ISSN-L)
DOI
10.1016/s1095-6433(01)00443-3
OpenAlex
W2048589001
Cited by
22
References
1
Citations by year
2024: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 2
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
beta-carotene, vitamin A, retinol-binding protein, retinyl esters, retinol, vitamin A metabolism, plasma transport, tissue distribution, urinary excretion, liver, kidney, cats, carotenoids
MeSH terms
Animals, Biological Transport, Cats, Electrophoresis, Polyacrylamide Gel, Female, Immunoglobulin G, Immunohistochemistry, Kidney, Kidney Medulla, Liver, Male, Palmitates, Plasma, Retinol-Binding Proteins, Stearates, Tissue Distribution, Vitamin A, beta Carotene, Oleic Acid, Hepatocytes, Retinol-Binding Proteins, Plasma

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