Variation of mucin distribution in the rat intestine, caecum and colon: effect of the bacterial flora
Abstract
The influence of the intestinal microflora on mucin types was studied in the small intestine, caecum and colon of conventional (CV) rats as compared to germ-free (GF) rats. A colorimetric method was used on purified water-soluble mucin extracted from mucosal scrapings and contents. Variations occurred between the three anatomical sites both in the mucosas and intestinal contents of GF rats. In CV rats, the presence of the bacterial flora led to different effects depending on the intestinal site: in the small intestinal mucosa, neutral and sulphomucins values were higher whereas sialomucin was much lower. Conversely, sialomucin was higher in the caecal and colonic mucosas and contents whereas sulphated mucins were decreased significantly in caecal contents and caecal and colonic mucosas. These variations in the contents may reflect the bacterial mucolytic activity and the effect of bacterial metabolites on the mucosa.
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Reintroduction of microbes via conventionalization elevates intestinal mucin levels.
“Previous studies have reported that the reintroduction of microbes via conventionalization elevates mucin levels in the intestine.51,52”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [51]
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References 24 · Cited by 55
- Authors
- Meslin, J.-C., Fontaine, N., & Andrieux, C.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Corresponding author
- Meslin, Jean-Claude
- Venue
- Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 123
- Issue
- 3
- Pages
- 235-239
- ISSN
- 1095-6433 (ISSN-L)
- OpenAlex
- W2025001015
- Cited by
- 55
- References
- 24
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Recherche Agronomique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Keywords
- intestinal mucin, gut microbiota, germ-free rats, conventional rats, small intestine, cecum, colon, sialomucin, neutral mucins, bacterial metabolites, intestinal contents
- MeSH terms
- Animals, Animal Feed, Bacteria, Cecum, Colon, Intestinal Mucosa, Intestine, Small, Intestines, Male, Mucins, Rats, Inbred F344, Sepharose, Specific Pathogen-Free Organisms, Rats, Sialomucins
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