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Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

Rawson, Robert B, Zelenski, Nikolai G, Nijhawan, Deepak, Ye, Jin, Sakai, Juro, Hasan, Mazahir T, Chang, T.Y, Brown, Michael S, Goldstein, Joseph L·1997·Molecular Cell
DOI 10.1016/s1097-2765(00)80006-4
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  • When SREBP-2 reaches the Golgi, S1P and S2P sequentially modify SREBP-2 to convert it to active nuclear SREBP-2.

    “When SREBP-2 reaches the Golgi, two proteases, site 1 protease (S1P) and site 2 protease (S2P), sequentially modify SREBP-2 to convert it to its active form, designated nuclear SREBP-2 (nSREBP-2)71–73.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [73]

    The Introduction says that Site-1 cleavage precedes Site-2 cleavage, which releases the SREBP fragment that can enter the nucleus and activate transcription. The paper does not place this sequential processing in the Golgi; its Golgi mention concerns a different protease, ECE-1. (LLM, conf=0.86)

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Metadata

Authors
Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. T., Chang, T. Y., Brown, M. S., & Goldstein, J. L.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
1997-12
Volume
1
Issue
1
Pages
47-57
ISSN
1097-2765
DOI
10.1016/s1097-2765(00)80006-4
Cited by
429
References
1
Language
en
Licence

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