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Three-Dimensional Architecture of the Isolated Yeast Nuclear Pore Complex: Functional and Evolutionary Implications
Open accessAbstract
We have calculated a three-dimensional map of the yeast nuclear pore complex (yNPC) from frozen-hydrated specimens, thereby providing a direct comparison with the vertebrate NPC. Overall, the smaller yNPC is comprised of an octagonal inner spoke ring that is anchored within the nuclear envelope by a novel membrane-interacting ring. In addition, a cylindrical transporter is located centrally within the spokes and exhibits a variable radial expansion in projection that may reflect gating. The inner spoke ring, a transmembrane spoke domain, and the transporter are conserved between yeast and vertebrates; hence, they are required to form a functional NPC. However, significant alterations in NPC architecture have arisen during evolution that may be correlated with differences in nuclear transport regulation or mitotic behavior.
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Citations
Cited by
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Ribbeck, K., & Görlich, D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1320 · Cited by 772
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Fromont-Racine, M., Senger, B., Saveanu, C., & Fasiolo, F. (2003) · Gene · doi:10.1016/s0378-1119(03)00629-2 · Cited by 593
A Saturated FG-Repeat Hydrogel Can Reproduce the Permeability Properties of Nuclear Pore Complexes
Frey, S., & Görlich, D. (2007) · Cell · doi:10.1016/j.cell.2007.06.024 · Cited by 567
Natively Unfolded Nucleoporins Gate Protein Diffusion across the Nuclear Pore Complex
Patel, S. S., Belmont, B. J., Sante, J. M., & Rexach, M. F. (2007) · Cell · doi:10.1016/j.cell.2007.01.044 · Cited by 566
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Chook, Y. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(01)00264-0 · Cited by 526
Metadata
- Authors
- Yang, Q., Rout, M. P., & Akey, C. W.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 1
- Issue
- 2
- Pages
- 223-234
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2105657024
- Cited by
- 342
- References
- 0
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yang, Q., Rout, M. P., & Akey, C. W. (1998). Three-Dimensional Architecture of the Isolated Yeast Nuclear Pore Complex: Functional and Evolutionary Implications. Molecular Cell. https://doi.org/10.1016/s1097-2765(00)80023-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
