A Role for Transcriptional Repressors in Targeting the Yeast Swi/Snf Complex
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Genetic and biochemical studies indicate that the evolutionarily conserved Swi/Snf complex acts at a subset of genes to help transcriptional activators function on chromatin templates. The mechanism by which this complex is targeted to specific chromosomal loci remains unknown. We show that Swi/Snf is required for expression of the yeast histone HTA1-HTB1 locus because of the role of Hir1p and Hir2p corepressors in negatively regulating transcription. Snf5p, Snf2p/Swi2p, and Swi3p, three components of the yeast Swi/Snf complex, coimmunoprecipitate with each Hir protein, and Snf5p is maximally associated with the HTA1-HTB1 promoter when the Hir-based repression system is intact and the Swi/Snf complex is functional. The data support a role for the Hir repressors in the gene-specific targeting of Swi/Snf.
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In the late G1 and early S phase, Rtt106 recruits SWI/SNF, which activates transcription of the histone genes by releasing HIR- and RSC-mediated repression.
“In contrast, in the late G1 and early S phase Rtt106 recruits SWI/SNF, another ATP-dependent chromatin-remodelling complex, which activates transcription of the histone genes by releasing HIR- and RSC-mediated repression33,34.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [34]
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References 90 · Cited by 105
- Authors
- Dimova, D., Nackerdien, Z., Furgeson, S., Eguchi, S., & Osley, M. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Osley, Mary Ann
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 4
- Issue
- 1
- Pages
- 75-83
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1973157808
- Cited by
- 105
- References
- 90
- Citations by year
- 2024: 1 · 2022: 3 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 5 · 2012: 6
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM040118, GM 40118)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- SWI/SNF complex, transcriptional repressor, histone H2A, chromatin remodeling, transcriptional repression, Saccharomyces cerevisiae
- MeSH terms
- SMARCB1 Protein, Adenosine Triphosphatases, Chromosomal Proteins, Non-Histone, DNA-Binding Proteins, Fungal Proteins, Histones, Mutation, Nuclear Proteins, Promoter Regions, Genetic, Repressor Proteins, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Fungal, Evolution, Molecular, Saccharomyces cerevisiae Proteins
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