A Mechanism of Cell Survival
Open accessAbstract
Death receptors such as Fas are present in a variety of organs including liver and play an important role in homeostasis. What prevents these harmful receptors from forming homooligomers, clustering, and initiating the apoptotic pathway is not known. Here, we report the discovery of a cell survival mechanism by which Met, a growth factor receptor tyrosine kinase, directly binds to and sequesters the death receptor Fas in hepatocytes. This interaction prevents Fas self-aggregation and Fas ligand binding, thus inhibiting Fas activation and apoptosis. Our results describe a direct link between growth factor tyrosine kinase receptors and death receptors to establish a novel paradigm in growth regulation.
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High doses of HGF can suppress mitosis or induce apoptosis.
“Since high doses of HGF can suppress mitosis [19] or induce apoptosis [20]”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [20]
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References 29 · Cited by 225
- Authors
- Wang, X., DeFrances, M. C., Dai, Y., Pediaditakis, P., Johnson, C., Bell, A., Michalopoulos, G. K., & Zarnegar, R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Zarnegar, Reza
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 9
- Issue
- 2
- Pages
- 411-421
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1989848888
- Cited by
- 225
- References
- 29
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 14 · 2012: 13
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA035373, R01-CA103958, R01CA95782-01, R01CA095782)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- Fas death receptor, MET receptor tyrosine kinase, hepatocytes, apoptosis inhibition, receptor sequestration, growth factor receptor signaling, liver homeostasis, cell survival
- MeSH terms
- Animals, Cell Survival, Humans, Liver Neoplasms, Membrane Glycoproteins, Mice, Transgenic, Models, Biological, Phosphorylation, Protein Binding, Protein Processing, Post-Translational, Recombinant Fusion Proteins, Tumor Cells, Cultured, Culture Media, Serum-Free, Apoptosis, Hepatocyte Growth Factor, fas Receptor, Proto-Oncogene Proteins c-met, Caspases, Hepatocytes, Protein Interaction Mapping, Arabidopsis Proteins, Fatty Acid Desaturases, Macromolecular Substances, Mice, Caspase 8, Fas Ligand Protein, Caspase 9
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