Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells
Open accessAbstract
There is increasing evidence that myeloid cells express several receptor families, which include both inhibitory and stimulatory isoforms. The expression of receptor isoforms with similar specificities but opposite functions on the same cell is intriguing. What might be the interplay between these receptors? Some clues to the answer to this question may come from recent studies on two myeloid receptor families: the ILT/LIR/MIR (immunoglobulin-like transcript/leukocyte Ig-like receptor/monocyte/macrophage Ig-like receptor) and the SIRP (signal-regulatory protein).
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LILRB proteins are type I transmembrane receptors predominantly expressed on hematopoietic cells.
“The LILRB proteins are type I transmembrane receptors predominantly expressed on hematopoietic cells14–20.”
From Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors (2025) · cites this paper as [14]
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References 69 · Cited by 53
- Authors
- Dietrich, J., Nakajima, H., & Colonna, M.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Colonna, Marco
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 2
- Issue
- 3
- Pages
- 323-329
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W2011470870
- Cited by
- 53
- References
- 69
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- inhibitory receptors, activating receptors, myeloid cells, receptor isoforms, receptor signaling, macrophages, dendritic cells
- MeSH terms
- Leukocyte Immunoglobulin-like Receptor B1, Animals, Antigens, Differentiation, Carrier Proteins, HLA Antigens, Humans, Leukocytes, Macrophages, Membrane Glycoproteins, Membrane Proteins, Phosphorylation, Receptors, Fc, Receptors, Immunologic, Antigens, CD, Neural Cell Adhesion Molecules, Neural Cell Adhesion Molecule L1, Ubiquitin-Protein Ligases
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