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Cited by 31T-cell and Retrovirus StudiesHIV Research and Treatmentinterferon and immune responses

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Using genetics to probe host-virus interactions; the mouse mammary tumor virus model

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Ross, Susan R·2000·Microbes and Infection
DOI 10.1016/s1286-4579(00)01275-2
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Abstract

It is clear that there is genetic variation among different individuals in their susceptibility to infection by viruses and other pathogens. Identification of the genes involved in conferring resistance or susceptibility to viral infection will allow us to understand both mechanisms of infection and pathogenesis and to develop reagents for treating or preventing them. Because of the large number of genetically well-characterized inbred mouse strains and the ability to generate targeted germ line mutations, this species is particularly well-suited for such analysis. This review focuses on how the use of genetics to study the retrovirus mouse mammary tumor virus allowed the dissection of both the viral infection pathway and the response of the host to this infection.

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Metadata

Authors
Ross, S. R.
Affiliations
University of Pennsylvania (US)
Corresponding author
Ross, Susan R
ORCID
Ross, Susan R
Venue
Microbes and Infection
Publisher
Elsevier BV
Published
2000-08
Volume
2
Issue
10
Pages
1215-1223
ISSN
1286-4579 (ISSN-L)
DOI
10.1016/s1286-4579(00)01275-2
OpenAlex
W1978699642
Cited by
31
References
1
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 1
FWCI
0.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbes and Infection (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
host-virus interaction, mouse mammary tumor virus, retroviruses, genetic susceptibility to infection, inbred mouse strains, germline mutations, host antiviral response, pathogenesis, resistance genes
MeSH terms
Animals, Disease Models, Animal, Female, Mammary Tumor Virus, Mouse, Mammary Neoplasms, Experimental, Mice, Mutant Strains, Mice, Transgenic, Retroviridae Infections, Tumor Virus Infections, Mice

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Ross, S. R. (2000). Using genetics to probe host-virus interactions; the mouse mammary tumor virus model. Microbes and Infection. https://doi.org/10.1016/s1286-4579(00)01275-2