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Kinetic analysis of enzyme systems with suicide substrate in the presence of a reversible competitive inhibitor, tested by simulated progress curves
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“This result suggests that the bioactivation of PPR occurred at the active site of CYP3A, and the competitive binding of ketoconazole in the active site of the host enzyme protected the enzyme from inactivation (Moruno-Davila et al., 2001).”
From Piperine Is a Mechanism-Based Inactivator of CYP3A (2020) · cites this paper as Moruno-Davila et al., 2001
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Research works printed but not linked: 19
- Waley, 1980, Kinetics of suicide substrates, Biochem. J., 185, 771, 10.1042/bj1850771 · DOI
- Waley, 1985, Kinetics of suicide substrates. Practical procedure for determining parameters, Biochem. J, 227, 843, 10.1042/bj2270843 · DOI
- Tudela, 1987, Transient-phase kinetics of enzyme inactivation induced by suicide substrates, Biochim. Biophys. Acta, 912, 408, 10.1016/0167-4838(87)90046-X · DOI
- Wang, 1990, Kinetics of suicide substrates, J. Theor. Biol., 147, 497, 10.1016/S0022-5193(05)80261-9 · DOI
- Kandatege, 1996, A general progress curve method for the kinetic analysis of suicide enzyme inhibitors, Anal. Biochem., 234, 175, 10.1006/abio.1996.0069 · DOI
- Wang, 1990, An alternative method for determining inhibition rate constants by following the substrate reaction, J. Theor. Biol., 142, 531, 10.1016/S0022-5193(05)80107-9 · DOI
- Burke, 1990, On the kinetics of suicide substrates, Biophys. Chem., 37, 81, 10.1016/0301-4622(90)88009-H · DOI
- Walsh, 1984, Suicide substrates, mechanism-based enzyme inactivators: recent developments, Annu. Rev. Biochem., 53, 493, 10.1146/annurev.bi.53.070184.002425 · DOI
- Garcı́a-Cánovas, 1987, Estudio cinético sobre la fase de transición de enzimas tipo Michaelis con inhibición lineal e hiperbólica, An. Quı́m., 83C, 219
- Garcı́a-Cánovas, 1987, Métodos para discriminar entre mecanismos clásicos de inhibición basados en la cinética de su fase de transición, An. Quı́m., 83C, 340
- Silverman, 1995, Mechanism-based enzyme inactivators, Methods in Enzymology, 249, 240, 10.1016/0076-6879(95)49038-8 · DOI
- Ghadermarzi, 1999, Influence of different types of effectors on the kinetic parameters of suicide inactivation of catalase by hydrogen, Biochim. Biophys. Acta, 1431, 30, 10.1016/S0167-4838(99)00021-7 · DOI
- Tudela, 1987, Kinetic characterisation of dopamine as a suicide substrate of tyrosinase, J. Enzym. Inhib., 2, 47, 10.3109/14756368709030356 · DOI
- Tudela, 1987, Transient-phase kinetics of enzyme inactivation induced by suicide substrates, Biochim. Biophys. Acta, 912, 408, 10.1016/0167-4838(87)90046-X · DOI
- Varón, 1999, Transient phase of enzyme reactions. Time course equations of the strict and the rapid equilibrium conditions and their computerized derivation, Biosystems, 50, 99, 10.1016/S0303-2647(98)00095-1 · DOI
- Fehlgerg, 1970, Klassische Runge-Kutta Formeln vierter und niedrigerer Ordnung mit Scherittweiten-Kontrolle und ihre Anwendung auf Wärmeleitungs-probleme, Computing, 6, 61, 10.1007/BF02241732 · DOI · Paper page
- Garcı́a-Sevilla, 2000, Use of a windows program for simulation of the progress curves of reactants and intermediates involved in enzyme-catalyzed reactions, Biosystems, 54, 151, 10.1016/S0303-2647(99)00071-4 · DOI
- Garrido-del Solo, 1992, Programa de ordenador para simular el comportamiento cinético de las reacciones enzimáticas, An. Quim., 88, 633
- Garcı́a-Cánovas, 1989, Experimental methods for kinetic study of suicide substrates, J. Enzyme Inhib., 3, 81, 10.3109/14756368909030367 · DOI
Cited by
Piperine Is a Mechanism-Based Inactivator of CYP3A
Cui, T., Wang, Q., Tian, X., Zhang, K., Peng, Y., & Zheng, J. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.119.088955 · Cited by 37
Metadata
- Authors
- Moruno-Dávila, M. A., Garrido-del Solo, C., Garcı́a-Moreno, M., Havsteen, B. H., Garcia-Sevilla, F., Garcia-Cánovas, F., & Varón, R.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 33
- Issue
- 2
- Pages
- 181-191
- ISSN
- 1357-2725
- Cited by
- 16
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- CoChat. (2026). Citation check: Kinetic analysis of enzyme systems with suicide substrate in the presence of a reversible competitive inhibitor, tested by simulated progress curves. https://app.cochat.ai/papers/10.1016/s1357-2725(00)00076-5
- The paper
- Moruno-Dávila, M. A., Garrido-del Solo, C., Garcı́a-Moreno, M., Havsteen, B. H., Garcia-Sevilla, F., Garcia-Cánovas, F., & Varón, R. (2001). Kinetic analysis of enzyme systems with suicide substrate in the presence of a reversible competitive inhibitor, tested by simulated progress curves. The International Journal of Biochemistry & Cell Biology. https://doi.org/10.1016/s1357-2725(00)00076-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.