The influence of the microenvironment on the malignant phenotype
Abstract
Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. As tissue becomes cancerous, there are reciprocal interactions between neoplastic cells, adjacent normal cells such as stroma and endothelium, and their microenvironments. The current dominant paradigm wherein multiple genetic lesions provide both the impetus for, and the Achilles heel of, cancer might be inadequate to understand cancer as a disease process. In the following brief review, we will use selected examples to illustrate the influence of the microenvironment in the evolution of the malignant phenotype. We will also discuss recent studies that suggest novel therapeutic interventions might be derived from focusing on microenvironment and tumor cells interactions.
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Carcinoma-associated fibroblasts are components of the so-called reactive stroma, which facilitates the progression of epithelial cancers.
“These carcinoma-associated fibroblasts are components of the so-called reactive stroma, which facilitates the progression of epithelial cancers (Olumi et al., 1999; Park et al., 2000; Tlsty and Hein, 2001).”
From Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors (2005) · cites this paper as Park et al., 2000
Many cells with oncogenic mutations are kept in check by the tissue microenvironment.
“Further, many cells with oncogenic mutations are kept in check by the tissue microenvironment (Park et al., 2000).”
From Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors (2005) · cites this paper as Park et al., 2000
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References 46 · Cited by 398
- Authors
- Park, C. C., Bissell, M. J., & Barcellos-Hoff, M. H.
- Affiliations
- Harvard University (US)
- Lawrence Berkeley National Laboratory (US)
- Venue
- Molecular Medicine Today
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 6
- Issue
- 8
- Pages
- 324-329
- ISSN
- 1357-4310 (ISSN-L)
- OpenAlex
- W2044828823
- Cited by
- 398
- References
- 46
- Citations by year
- 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 9 · 2019: 13 · 2018: 12 · 2017: 15 · 2016: 13 · 2015: 14 · 2014: 13 · 2013: 21 · 2012: 18
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Medicine Today (publishedVersion)
- PubMed (publishedVersion)
- Molecular Medicine Today
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- tumor microenvironment, malignant phenotype, endothelial cells, tumor progression, tissue homeostasis, tumor stroma, tumor cell-microenvironment interactions, cancer therapy
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Extracellular Matrix, Homeostasis, Humans, Neoplasms, Phenotype, Radiation, Ionizing, Wounds and Injuries, Integrins, Transforming Growth Factor beta
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