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Role of Oncostatin M in hematopoiesis and liver development
Abstract
Definitive hematopoietic stem cells (HSCs) first appear in the aorta/gonad/mesonephros (AGM) region and migrate to the fetal liver where they massively produce hematopoietic cells before establishing hematopoiesis in the bone marrow at a perinatal stage. In the AGM region, Oncostatin M (OSM) enhances the development of both hematopoietic and endothelial cells by possibly stimulating their common precursors, so-called hemangioblasts. During development of HSCs in the AGM region, the liver primodium is formed at the foregut and accepts HSCs. While fetal hepatic cells function as hematopoietic microenvironment for expansion of hematopoietic cells during mid to late gestation, they do not possess most of the metabolic functions of adult liver. Along with the expansion of hematopoietic cells in fetal liver, OSM is produced by hematopoietic cells and induces differentiation of fetal hepatic cells, conferring various metabolic activities of adult liver. Matured hepatic cells then lose the ability to support hematopoiesis. Thus, OSM appears to coordinate the development of liver and hematopoiesis in the fetus.
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“These cytokines have been implicated in liver functions such as development, hepatocyte differentiation, or inflammation (31)(32)(33), but have yet to be examined in liver regeneration.”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [31]
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Metadata
- Authors
- Miyajima, A., Kinoshita, T., Tanaka, M., Kamiya, A., Mukouyama, Y., & Hara, T.
- Affiliations
- Kanagawa Academy of Science and Technology (JP)
- The University of Tokyo (JP)
- Corresponding author
- Miyajima, Atsushi
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 11
- Issue
- 3
- Pages
- 177-183
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2073807783
- Cited by
- 153
- References
- 60
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- oncostatin M, hematopoiesis, liver development, hematopoietic stem cells, aorta-gonad-mesonephros, fetal liver, hemangioblasts, hematopoietic microenvironment, cytokine signaling
- MeSH terms
- Animals, Aorta, Gonads, Growth Inhibitors, Hematopoiesis, Humans, Liver, Mesonephros, Peptides, Receptors, Cytokine, Receptors, Oncostatin M, Oncostatin M
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