The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Connective tissue growth factor: a mediator of TGF-β action on fibroblasts
Open accessAbstract
Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds heparin and is secreted by fibroblasts after activation with transforming growth factor beta (TGF-beta). CTGF is a member of a highly conserved family of peptides that include immediate early gene products cef10, cyr61, fisp12; a putative avian proto-oncogene, nov; and a drosophila gene, twisted gastrulation, tsg, that controls medial mesoderm induction during dorsal-ventral axis pattern formation, a process also controlled by TGF-beta related peptides (dpp, scw). In the adult mammal, CTGF functions as a downstream mediator of TGF-beta action on connective tissue cells, where it stimulates cell proliferation and extracellular matrix synthesis. CTGF does not appear to act on epithelial cells or immune cells. Because the biological actions of TGF-beta are complex and affect many different cell types, CTGF may serve as a more specific target for selective intervention in processes involving connective tissue formation during wound repair or fibrotic disorders. Northern blot and in situ hybridization studies have demonstrated that CTGF is coordinately expressed with TGF-beta in every fibrotic disorder examined to date. Agents that inhibit CTGF production or action could lead to the development of new therapeutic approaches for the control of fibrotic disorders in humans.
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Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Kireeva, M. L., Mo, F.-E., Yang, G. P., & Lau, L. F. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1326 · Cited by 341
Expression of cyr61, a growth factor-inducible immediate-early gene.
O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3569 · Cited by 310
Identification of a Gene Family Regulated by Transforming Growth Factor-β
Brunner, A., Chinn, J., Neubauer, M., & Purchio, A. F. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.293 · Cited by 124
Cited by
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319
Liver fibrosis – from bench to bedside
Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780
TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
Kasai, H., Allen, J. T., Mason, R. M., Kamimura, T., & Zhang, Z. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-56 · Cited by 744
Duncan, M. R., Frazier, K. S., Abramson, S., Williams, S., Klapper, H., Huang, X., & Grotendorst, G. R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.13.1774 · Cited by 631
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Metadata
- Authors
- Grotendorst, G. R.
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 8
- Issue
- 3
- Pages
- 171-179
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W1964941505
- Cited by
- 761
- References
- 4
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Grotendorst, G. R. (1997). Connective tissue growth factor: a mediator of TGF-β action on fibroblasts. Cytokine & Growth Factor Reviews. https://doi.org/10.1016/s1359-6101(97)00010-5
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