Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation
Abstract
In recent years many efforts have been undertaken to elucidate the complex interactions between mediators of the endocrine system and the immune system. The main effector of growth hormone (GH) is insulin-like growth factor-1 (IGF-1), an endocrine mediator of growth and development under physiological conditions. Besides this important function, IGF-1 also plays a prominent role in the regulation of immunity and inflammation. This article will address the involvement of IGF-1 in innate as well as acquired immunity and host-defense. We also discuss the role of IGF-1 in the course of inflammatory disorders, including sepsis and sepsis-induced catabolism as well as degenerative arthritis. Based on recent insights, we finally examine the pathophysiological background, potential pitfalls and perspectives of IGF-1 suppletion therapy in these conditions.
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IGF-1 has mainly pro-inflammatory effects.
“IGF-1 was demonstrated to have mainly pro-inflammatory effects [83,84].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [83]
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References 116 · Cited by 182
- Authors
- Heemskerk, V. H., Daemen, M. A. R. C., & Buurman, W. A.
- Affiliations
- Maastricht University (NL)
- Corresponding author
- Buurman, Wim A
- ORCID
- Buurman, Wim A
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 10
- Issue
- 1
- Pages
- 5-14
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2095178432
- Cited by
- 182
- References
- 116
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 9 · 2016: 7 · 2015: 12 · 2014: 7 · 2013: 8 · 2012: 5
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- insulin-like growth factor I, growth hormone, immunity, inflammation, innate immunity, adaptive immunity, host defense, sepsis, osteoarthritis
- MeSH terms
- Animals, Humans, Immunity, Inflammation, Insulin-Like Growth Factor I, Osteoarthritis, Growth Hormone, Sepsis
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