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Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants
Open accessAbstract
The use of plants for medicinal purposes dates back thousands of years but genetic engineering of plants to produce desired biopharmaceuticals is much more recent. As the demand for biopharmaceuticals is expected to increase, it would be wise to ensure that they will be available in significantly larger amounts, on a cost-effective basis. Currently, the cost of biopharmaceuticals limits their availability. Plant-derived biopharmaceuticals are cheap to produce and store, easy to scale up for mass production, and safer than those derived from animals. Here, we discuss recent developments in this field and possible environmental concerns.
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Cited by
Plants and human health in the twenty-first century
Raskin, I., Ribnicky, D. M., Komarnytsky, S., Ilic, N., Poulev, A., Borisjuk, N., Brinker, A., Moreno, D. A., Ripoll, C., Yakoby, N., et al. (2002) · Trends in Biotechnology · doi:10.1016/s0167-7799(02)02080-2 · Cited by 913
Daniell, H., Lee, S.-B., Panchal, T., & Wiebe, P. O. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4921 · Cited by 398
Self-citationExpression of Recombinant Antibodies
Frenzel, A., Hust, M., & Schirrmann, T. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00217 · Cited by 353
Cyanobacterial Production of Biopharmaceutical and Biotherapeutic Proteins
Betterle, N., Hidalgo Martinez, D., & Melis, A. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00237 · Cited by 33
Metadata
- Authors
- Daniell, H., Streatfield, S. J., & Wycoff, K.
- Venue
- Trends in Plant Science
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 6
- Issue
- 5
- Pages
- 219-226
- ISSN
- 1360-1385 (ISSN-L)
- OpenAlex
- W1966491512
- Cited by
- 750
- References
- 0
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Daniell, H., Streatfield, S. J., & Wycoff, K. (2001). Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends in Plant Science. https://doi.org/10.1016/s1360-1385(01)01922-7
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