Overview of structural genomics: from structure to function
Abstract
The unprecedented increase in the number of new protein sequences arising from genomics and proteomics highlights directly the need for methods to rapidly and reliably determine the molecular and cellular functions of these proteins. One such approach, structural genomics, aims to delineate the total repertoire of protein folds, thereby providing three-dimensional portraits for all proteins in a living organism and to infer molecular functions of the proteins. The goal of obtaining protein structures on a genomic scale has motivated the development of high-throughput technologies for macromolecular structure determination, which have begun to produce structures at a greater rate than previously possible. These new structures have revealed many unexpected functional and evolution relationships that were hidden at the sequence level.
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Structure is more informative of function than sequence and structure is encoded by sequence.
“Although structure is more informative of function than sequence 57,58 and structure is encoded by sequence, predicting structure remains hard, particularly due to the relative paucity of structural relative to sequence data.”
From Learning the protein language: Evolution, structure, and function (2021) · cites this paper as [57]
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Learning the protein language: Evolution, structure, and function
Bepler, T., & Berger, B. (2021) · Cell Systems · doi:10.1016/j.cels.2021.05.017 · Cited by 483 · see citing works
Protein Function Prediction Using Local 3D Templates
Laskowski, R. A., Watson, J. D., & Thornton, J. M. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.067 · Cited by 213 · see citing works
- Authors
- Zhang, C., & Kim, S.-H.
- Affiliations
- Lawrence Berkeley National Laboratory (US)
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 7
- Issue
- 1
- Pages
- 28-32
- ISSN
- 1367-5931 (ISSN-L)
- OpenAlex
- W2083339788
- Cited by
- 154
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 11 · 2013: 5 · 2012: 1
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM62412, P50GM062412)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- structural genomics, protein structure determination, protein fold, protein function prediction, protein evolution, protein 3D structure
- MeSH terms
- Amino Acid Sequence, Proteins, Structure-Activity Relationship, Sequence Alignment, Genomics
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